Can I Mix CBD Oil With Melatonin


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It isn’t known for sure if it’s safe to mix melatonin and weed, so talk to your healthcare provider before mixing the two. Learn more. We spoke with Chris Adlakha, PharmD of Elevated Wellness who shares with us the incredible side effects of CBD and melatonin.

Is it safe to mix melatonin and weed?

There are no scientific studies that answer if it’s safe to mix melatonin and weed, but it’s thought that combining these two substances might increase side effects like drowsiness. There’s also some evidence that occasional weed gives your natural melatonin production a boost, so taking a melatonin supplement might not even be necessary.

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If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

The legalization of marijuana (also known as cannabis or weed) for medical and recreational use is happening in many states (Bowles, 2017). As a result, more people are trying weed and have questions about what it shouldn’t be mixed with. One such question is: Is it safe to mix melatonin supplements and weed?

While there have yet to be formal studies on the safety of mixing weed with melatonin, it’s always better to err on the side of caution and speak with your healthcare provider prior to mixing the two due to the side effects each substance can have. Let’s learn a little more about how weed and melatonin affect the body.

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Can you mix melatonin and weed?

If you’re questioning if it’s safe to combine weed and melatonin, a supplement often used as a short-term sleep aid, there isn’t a clear answer. The medical community needs to conduct more research before it can safely answer this question, and to date, scientists haven’t done any formal clinical studies to test the combination.

But we do know that both melatonin and weed can make you sleepy, so combining the two could potentially lead to more drowsiness and sedation than you expected. To be on the safe side, if you use medical marijuana or if you partake recreationally, it is best to consult your healthcare provider before combining it with a melatonin supplement.

Side effects of mixing melatonin and weed

Just because something is “natural” doesn’t mean it’s safe, especially when you mix it with other things. The combined side effects of taking melatonin supplements and weed aren’t known for sure, but separate studies of each substance show that they can cause side effects.

Common side effects reported with marijuana use include (Whiting, 2015):

  • Dizziness
  • Dry mouth
  • Nausea and vomiting
  • Sleepiness
  • Euphoria (feeling “high”)
  • Reduced awareness of time and surroundings
  • Confusion
  • Loss of balance

People take melatonin supplements before they go to bed. They don’t typically cause side effects, but there have been reports of higher doses causing drowsiness, nausea, and headaches (Savage, 2021).

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The concern is that having both of these substances in your system simultaneously could make the overlapping side effects (nausea and drowsiness) worse. Keep in mind that drinking alcohol with melatonin supplements could also make these side effects—and your sleep quality—worse.

Melatonin vs. weed for sleep

Some research suggests that cannabis could alter the sleep-wake cycle and increase natural melatonin levels (Bowles, 2017). Also, tetrahydrocannabinol (THC), the main active compound in weed, binds with specific receptors in the brain and leads to sedation or drowsiness (Ramar, 2018).

So, if your body’s natural melatonin gets a boost from weed, and its active ingredient can make you feel sleepy, then it doesn’t seem necessary to take a melatonin supplement before going to bed.

Like melatonin, people commonly use weed as a sleep aid. But there seems to be a difference in how well weed works for sleep if you use it daily compared to occasional use.

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One study’s results showed that daily cannabis use was associated with more sleep disturbances compared to twice-per-week cannabis use (Conroy, 2016). Another study found that most heavy marijuana users had trouble getting seven to nine hours of sleep per night and also reported poor sleep quality (Pacek, 2017). So, if you smoke or consume weed heavily and have sleep problems, it might be worth trying to cut back on the weed to see if your sleep improves.

Using melatonin or weed for sleep disorders

When it comes to the long-term treatment of sleep disorders like insomnia, the American Academy of Sleep Medicine (AASM) does not recommend melatonin as a sleep aid due to the lack of strong evidence behind it. They do not mention weed in these guidelines at all (Sateia, 2017).

But, the AASM specifically recommends against the use of medical cannabis as a sleep aid in people with a condition called obstructive sleep apnea (OSA). With OSA, you stop breathing for short periods during sleep (Ramar, 2018).

What about mixing melatonin and CBD?

Cannabidiol (CBD) is the second most prevalent component in weed (marijuana) and doesn’t cause a “high.”

Some cannabinoid supplements that contain both melatonin and CBD are currently available. These products may be promoted as sleep aids. But, in the United States, dietary supplements are not required to obtain approval from the Food and Drug Administration (FDA). Clinical studies are ongoing, but there’s no strong evidence to back up the safety or effectiveness of these CBD blend supplements (Kaul, 2021).

When to talk to a healthcare provider

Before combining sedating substances like melatonin and weed, it is best to talk to a healthcare professional. This is especially important if you’re pregnant, breastfeeding, have epilepsy, or have other medical conditions.

Also, if you’re having trouble getting a good night’s sleep, a healthcare provider can help. They’ll want to check you for any undiagnosed health condition that could be causing insomnia or making it worse. If they can identify and treat an underlying reason, the hope is that you won’t need to take anything—or consider mixing substances—to help you fall asleep. Instead, getting into healthy bedtime routines, like limiting screen time before bed, can be helpful.

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The Incredible Side Effects of Taking CBD With Melatonin

Trying to get a solid night’s sleep when you suffer from insomnia is a truly frustrating challenge that so many Americans unfortunately deal with. If you struggle with this chronic issue, we are here to let you in on a way to sleep deeper and overall so much better by combining CBD and melatonin. You heard that right!

Eat This, Not That! spoke with Chris Adlakha, PharmD of Elevated Wellness who shares with us, “CBD can help regulate REM sleep for deeper and longer sleep, while melatonin helps with sleep onset. CBD on its own is often not very sedating, so melatonin can really help you fall asleep quicker.” Read on to learn more about the positive effects CBD and melatonin can have on your nighttime snooze. And next, don’t miss The 6 Best Exercises for Strong and Toned Arms in 2022, Trainer Says.

CBD can be ultra-effective when it comes to getting a great night’s rest

CBD is so effective when it comes to improving your sleep, and Adlakha explains exactly why. Many negative symptoms you may be feeling from certain conditions can be relieved by taking CBD. Some conditions include inflammation, restless leg syndrome, stress, over-active minds, mental anguish, light or insufficient REM sleep, pain, overly vivid dreaming, and just about every condition you may be dealing with. Chronic issues can negatively impact your ability to sleep. The fact that CBD can address just about all of these things—based on the particular formulation—CBD is a natural choice to help you get the restful Z’s you are longing for.

Adlakha does caution, “This doesn’t mean any CBD product will help. Really, people should look for CBD products that contain more indica-dominant cannabinoids, terpenes, and flavonoids (CBN, THC, Myrcene, Linalool, etc), or find a solution that combines cannabis compounds and melatonin, or even other adaptogens or nootropics (like L-theanine, Pharma-GABA, etc.).”

The Sleep Aid Max is “a full spectrum CBD Tincture” infused with Premium Grade Melatonin for solid relaxation

If you’re having difficulty falling and staying asleep, it’s always wise to try to identify what may be causing the problem in the first place. Adlakha recommends the Sleep Aid Max, which is made to be “fail-safe.” This product works on the majority of problems that cause sleep-related issues. And if you’re wondering what makes this product so effective, Adlakha explains that their sleeping aids are “fully ultrasonic homogenized.” That means your body absorbs them more, also known as bioavailability. 6254a4d1642c605c54bf1cab17d50f1e

The 2000mg Sleep Aid Tincture, according to Adlakha, “is a CBD isolate with 300mg of melatonin (66.6mg CBD / 10mg melatonin per mL) suspended in an organic MCT oil.” He also tells us, “Sleep Aid MAX is a full spectrum tincture with boosted CBN and THC, with a light (almost micro) dose of melatonin, and includes a terpene infusion with indica-based cannabis terpenes that are organic and kosher,” adding, “The Sleep Aid MAX is also ultrasonic homogenized into organic MCT oil.”

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If you decide to use the product, it’s recommended to take it about 1/2 hour to 1 hour prior to heading to sleep. You’ll put 1/2 to 1 ml underneath your tongue, keep it there for around 60 seconds, and then swallow. Consistency is strongly recommended—it should be taken each night to achieve the best results. On average, the product’s highest results seem to occur between 2 to 3 hours after dosing, although some reach peak performance earlier or later since everyone’s body chemistry varies. Adlakha also stresses, “We like to recommend users (especially new to cannabis users) take it low and slow. In other words, they should start with a lower dose and try that for a few nights (up to 7 nights) before deciding to increase their dosage. Some may only need to take as needed, and that’s completely okay as well.”

Taking CBD or cannabis compounds with melatonin could help with the side effects of taking melatonin by itself

In case you are wondering, melatonin by itself can totally be a sleep helper and assist with longer REM sleep, but Adlakha warns, “There can be inherent issues for certain body chemistries.” The reason is simple. Some individuals are suddenly awakened by pretty realistic dreams that can be a reaction to taking melatonin by itself. Melatonin also won’t be much of a pain reliever or aid with issues such as stress, restless leg syndrome, etc.

Adlakha advises, “Having CBD or cannabis compounds along with melatonin can help with issues that affect sleep, but can also calm down some of the side effects involved with melatonin, like excessive vivid dreaming/nightmares, etc. We believe it’s not entirely a good idea to rely on melatonin alone, as users tend to have to take more and more over time.” Too much melatonin can actually compromise the body’s natural production of melatonin. Supplementing with cannabis compounds can potentially avoid that risk—especially if you use a cannabis solution that contains minimal to no melatonin. (The Sleep Aid MAX and Terpene Infused Relax Line contain absolutely no melatonin).

This powerhouse duo can address greater sleep issues that negatively impact Z’s

Cannabis and melatonin make a great combo for individuals with greater sleep issues, such as difficulty getting to sleep because of an overactive mind, or inflammation and pain that negatively impact sleep. The two products together have been majorly successful recently.

Adlakha stresses, “Melatonin may not be entirely necessary if the right formulation of cannabis chemicals is present in the product.” He explains if you’re able to repair your sleep problem successfully without supplementing with melatonin (or higher melatonin doses), you’re on a good track. Interestingly, the human body typically produces enough melatonin on its own to work well with the dose of CBD. “Some people really want the melatonin included, and some body chemistries lack the ability to produce sufficient levels of natural melatonin, which makes supplementing CBD with melatonin a helpful, useful, and effective addition,” he explains.

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