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cannabis and anxiety research

May relieve anxiety temporarily

Several studies have found that long-term marijuana use can cause memory loss. Memory impairment occurs because THC alters one of the areas of the brain, the hippocampus, responsible for memory formation. It also can have negative consequences on the brain’s motivation system.

Potential Benefits and Risks

Can create psychological dependence

The scientific community has recently started examining the effect of cannabis on anxiety, and the verdict is that short-term benefits do exist.

The use of certain prescription medications such as the selective serotonin reuptake inhibitors (SSRIs) have been firmly established as safe and effective treatment for anxiety disorders.  

Figure 2 presents the results of the measurements with LSAS of the level of the symptoms that are associated with SAD. The results were strikingly similar to those shown in Figure 1. The main effect was statistically significant for MEASUREMENT (F1,35 = 10.35, p = 0.003, η p 2 = 0.023) but not for PARTICIPANT (F1,35 = 0.45, p = 0.57, η p 2 = 0.011). The interaction between these factors was significant (F1,35 = 39.16, p < 0.001, η p 2 = 0.528). The mean LSAS score (SD) of the CBD group was 74.2 (7.5) in the preintervention measurement and 62.1 (8.7) in the postintervention measurement and that of the placebo group was 69.9 (10.3) in the preintervention measurement and 66.8 (11.2) in the postintervention measurement.

Devinsky, O., Marsh, E., Friedman, D., Thiele, E., Laux, L., Sullivan, J., et al. (2016). Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 15, 270–278. doi: 10.1016/S1474-4422(15)00379-8

Design and Participants

Scuderi, C., Filippis, D. D., Iuvone, T., Blasio, A., Steardo, A., and Esposito, G. (2009). Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Psychother. Res. 23, 597–602. doi: 10.1002/ptr.2625

Whiting, P. F., Wolff, R. F., Deshepande, S., Di Nisio, M., Duffy, S., Hemandez, A. V., et al. (2015). Cannabinoids for medical use: a systematic review and meta-analysis. JAMA 313, 2456–2473. doi: 10.1001/jama.2015.6358

Saito, T. (2007). Why hikikomori is cured? Tokyo: Chuo Hoki Press, 1–138.