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cbd and cholesterol

When you ingest Cannabinoids, the CBD engages with your endocannabinoid system (which is present in many organs in your body) and reduces inflammation. Chronic inflammation is found in a large population of our society, with people suffering from heart disease, cancer, Alzheimer’s disease, autoimmune disease and more. Taking a touch of CBD oil can combat this type of pain.

People have been using CBD to help with their mental health for centuries, with one recorded use all the way back in 2000 BCE. In human and animal studies, CBD has been shown to lessen stress and anxiety, notably in cases of social anxiety disorder. Research has also shown that people suffering from post-traumatic stress disorder have been able to use CBD as part of their healing process. The antidepressant-like effects provide the user with depression relief without annoying side effects.

4. Reduces Risk of Obesity

While marijuana use is known for giving users “the munchies”, several studies have shown that regular cannabis users actually have a lower body mass index than those who do not use CBD.

The New England Journal of Medicine published a study sharing that CBD oil has successfully helped children who have neurological disorders like epilepsy or forms of epilepsy, without any side effects. According to the study, children taking CBD had 23% fewer seizures than those taking the placebo.

CBD, which is an abbreviation for cannabidiol, is a chemical compound found in the cannabis plant. However, it contains untraceable amounts of tetrahydrocannabinol (THC), meaning that taking CBD oil will not get you high. And no, you will not fail any drug test by taking CBD oil.

CBD Oil and Cholesterol

Bile Acid Binding Resins

Injectable medications are a broad category, but fundamentally, they are focused on lowering the amount of cholesterol that is free in your blood.

What Is Cholesterol?

If you eat a diet that is particularly high in saturated and trans fats, then you are likely to suffer from a higher than acceptable level of cholesterol. Furthermore, being obese or weighing more than you should, in general, will also put you at risk of developing high cholesterol.

CBD oil is one of those things that has been used to treat all kinds of different and exciting medical conditions. But cholesterol is easily one of the oldest problems considered by cannabinoid users. There is a substantial amount of evidence showing that CBD oil could help reduce cholesterol and overall improve your heart health.

But first, what kind of treatment options are available before considering CBD oil? How do doctors traditionally treat cholesterol with conventional medicine?

Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that is clinically used in a 1:1 mixture with the psychoactive cannabinoid Δ(9)-tetrahydrocannabinol (THC) for the treatment of neuropathic pain and spasticity in multiple sclerosis. Our group previously reported that CBD exerts anti-inflammatory effects on microglial cells. In addition, we found that CBD treatment increases the accumulation of the endocannabinoid N-arachidonoyl ethanolamine (AEA), thus enhancing endocannabinoid signaling. Here we proceeded to investigate the effects of CBD on the modulation of lipid-related genes in microglial cells. Cell viability was tested using FACS analysis, AEA levels were measured using LC/MS/MS, gene array analysis was validated with real-time qPCR, and cytokine release was measured using ELISA. We report that CBD significantly upregulated the mRNAs of the enzymes sterol-O-acyl transferase (Soat2), which synthesizes cholesteryl esters, and of sterol 27-hydroxylase (Cyp27a1). In addition, CBD increased the mRNA of the lipid droplet-associated protein, perilipin2 (Plin2). Moreover, we found that pretreatment of the cells with the cholesterol chelating agent, methyl-β-cyclodextrin (MBCD), reversed the CBD-induced increase in Soat2 mRNA but not in Plin2 mRNA. Incubation with AEA increased the level of Plin2, but not of Soat2 mRNA. Furthermore, MBCD treatment did not affect the reduction by CBD of the LPS-induced release of the proinflammatory cytokine IL-1β. CBD treatment modulates cholesterol homeostasis in microglial cells, and pretreatment with MBCD reverses this effect without interfering with CBD’s anti-inflammatory effects. The effects of the CBD-induced increase in AEA accumulation on lipid-gene expression are discussed.