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cbd heart disease

However, it also notes that this research is still in the early stages, and that more studies are needed before conclusions can be drawn on whether CBD is effective.

“In terms of the products found in shops, there’s virtually no evidence to support the claims made for a lot of them.” Harry Sumnall, Professor in Substance Use at Liverpool John Moores University

What CBD products are available?

Prices can be high: a 500mg bottle of CBD oil oral drops could set you back as much as £45. Not that this has put people off: over the past two years, sales of CBD have almost doubled in the UK, putting regular users at an estimated quarter of a million.

A 2018 report by the World Health Organization suggested that CBD may help treat symptoms relating to conditions such as cancer, Parkinson’s disease, multiple sclerosis (MS), anxiety, depression, insomnia and Alzheimer’s disease.

Inflammation is part of the process that leads to many diseases, including coronary heart disease, high blood pressure and stroke, and there is some evidence that CBD has anti-inflammatory properties. Other studies have suggested that CBD can have a protective effect on the heart: this has been proven in rats after a heart attack and in mice with some of the heart damage associated with diabetes. But because these studies are often based on findings in a lab or in animals, not in humans, we cannot yet be confident that CBD will benefit the human heart.

Lowering your blood pressure is, therefore, crucial to reducing your risk of heart disease and this is where CBD can help. Researchers have found that CBD can lower blood pressure by widening blood vessels and enabling the blood to flow more easily. During a 2017 study , researchers learned that one dose of CBD reduced blood pressure in healthy participants.

CBD works with the endocannabinoid system (ECS), but before expanding on how it affects your body, it is important to know that it will not make you high. Two main natural compounds are extracted from the cannabis plant. There is CBD, also known as cannabinol and THC, also known as tetrahydrocannabinol.

Heart arrhythmias happen when the electrical impulses in your body help coordinate your heartbeats when they aren’t working as they should. As a result, it can beat slower, faster, or irregular. While some heart arrhythmias are harmless, others can be life-threatening.

Lowering Blood Pressure

When blood vessels’ pressure occurs for years, it can start forming bulges, known as aneurysms. If one of these bulges ruptures, internal bleeding would be the result that could lead to fatal consequences. High blood pressure may also be the culprit of an enlarged heart when it’s forced to work harder to pump blood, leading to a higher risk of a heart attack. Hypertension can also cause heart failure and coronary artery disease, both of which lead to chest pains and heart attacks.

CBD could affect your current medication and lead to complications. Moreover, a professional can guide you into choosing the right CBD for you, as some can still contain a high percentage of THC.

One report conducted by researchers at the Imperial College London noted how CBD contains significant anti-inflammatory properties, even higher than the usual contenders such as antioxidants, Omega-3 and vitamin C. When mice were given 5 mg of CBD, their inflammation was diminished by 50 percent.

Treating this medical condition is the job of thousands of medical professionals who work to prevent patients from suffering from fatal strokes or heart attacks. However, the medication to treat heart disease comes with a list of side effects that can cause other complications, so a safer alternative is ideal.

Ali et al. [22] observed the effects of CBD on the contractility and electrophysiological properties of rat ventricular myocytes. The results indicate that the inhibition of Ca 2+ signaling underlies the negative inotropic effects of CBD in myocytes, presenting a reduction in maximal shortening amplitudes with no alteration of the time course of contraction. However, Robertson-Gray et al. [23] observed a cardioprotective effect of CBD against l-α-lysophosphatidylinositol (LPI), an endogenous ligand of G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, which is also elevated in patients with the coronary syndrome. The injury was decreased by CBD acting as an antagonist of the GPR55 receptor. A similar effect of GPR55 antagonism was observed by Marichal-Cancino et al. [24], as CBD blocked the LPI-induced inhibition of vasopressor responses produced by noradrenaline, suggesting this receptor may play a role in CBD’s effects.

In arteries, the CBD enhanced COX activity, stimulating the production of prostaglandin E2, a potent smooth muscle vasodilator, activating EP4 receptors as described by Wheal et al. [26, 35]. In the endothelium, the COX activity may be mediated by the acetylcholine (ACh) via eNOS activation [26, 35]. CBD is known to suppress cellular adenosine intake, hence increasing its interstitial concentration and resulting in increased

2.2. Cardiovascular Effects of CBD Observed In Vitro

Jadoon et al. [95] reported CBD’s impact on blood pressure in healthy humans after an oral dose of 600 mg. In the study, the acute CBD administration reduced resting blood pressure and attenuated increases in blood pressure due to stressful situations. There are 247 clinical trials involving cannabidiol listed in the US National Library of Medicine database; most of them focus on pain relief and epilepsy, and four trials involve the measurement of cardiovascular parameters. An active study of oral dietary CBD supplements [96] in young and older healthy humans focuses on improving our understanding of how CBD might control and regulate blood vessel health, as well as cognitive and exercise performance, and includes systolic and diastolic blood pressure and heart rate measures. A completed study that assessed the effects of oral CBD (0, 200, 400, or 800 mg/Kg) on smoked marijuana’s subjective, reinforcing, cognitive, and cardiovascular effects [97] evaluated the effect of CBD on the heart rate when smoking marijuana. The study showed an increase in heart rate 15 min after the inhalation of THC (5.3%/cigarette), but it decreased over time, and no improvement was found in control participants (0.01% TCH/cigarette). They found no significant effects of CBD alone on the heart rate at every concentration. Another study aims at assessing the potential cardiovascular risks and benefits of CBD therapy in children with severe epilepsy [98] by characterizing CBD’s effects on EKG findings, heart rate variability, and the occurrence of seizures. The measures include Holter SDNN parameter changes, seizure frequency, and dysautonomia signs and symptoms.

The data used to support the findings of this study are available from the corresponding author upon request.

JA Garza Cervantes and M Ramos-González contributed equally to this work.