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cbd oil and hydrocodone

There are a variable of published studies that suggest that while CBD does inhibit metabolizing enzymes, it is not significant and the amount of CBD needed to affect these metabolizing enzymes in humans far exceeds what is possible with common dosing and consumption.

Below, we discuss the current evidence available regarding CBD and potential interactions with hydrocodone, including a potential decrease in efficacy of the pain relieving drug.

Nevertheless, based on the data available, the combination of CBD and hydrocodone appears relatively safe. There does not appear to be a risk of additive respiratory depression when using hydrocodone and CBD, a major consideration when combining hydrocodone with other drugs.

Taking Hydrocodone With CBD (Cannabidiol)

However, hydrocodone is metabolized in the body by CYP 2D6 to hydromorphone, which is significantly more potent than hydrocodone and mainly responsible for the analgesic effects of the drug. Therefore, potential metabolism inhibition by CBD could theoretically decrease the effectiveness of hydrocodone (due to less conversion to hydromorphone).

One study evaluated the use of CBD and fentanyl, one of the most potent opioids available. Per the study:

However, there is a theoretical interaction between CBD and hydrocodone where the effectiveness of hydrocodone in relieving pain could be decreased.

In our latest question and answer, the pharmacist discusses whether or not CBD (cannabidiol) products interact with hydrocodone.

It is reported that the bioavailability of CBD is 31% following smoking – in other words, only 31% of the CBD inhaled while smoking will make it into the blood. Oral bioavailability of CBD is estimated to be only 6-19% due to significant first-pass metabolism of CBD in the liver.

Medications with anticholinergic activity such as amitriptyline (Elavil) and doxepin, and muscle relaxers such as cyclobenzaprine (Flexeril) may increase the psychoactive side effccts of cannabinoids.

See also:

Alcohol and Benzodiazepines

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