Posted on

cbd oil and lymphoma

Lymphoma affects the way white blood cells called lymphocytes behave. Lymphocytes are critical for immunity and are antagonistic towards viruses and bacteria. Hodgkin’s lymphoma infects the cells responsible for making antibodies.

Hodgkin’s lymphoma turns off the body’s seek and destroy system. Cells that would have been targeted and flushed are now able to multiply as they please. This manifests in the body as swollen lymph nodes, usually in the chest and armpits.

CANNABIS AND QUALITY OF LIFE

Cannabis can be a powerful therapeutic tool. It has helped many people with a number of conditions. Can it aid people with Hodgkin’s lymphoma and give them a better quality of life?

Whether cannabis can be effective in the direct fight against Hodgkin’s lymphoma remains to be seen. However, it may be able to help the patient in a number [6] of other ways. Appropriate use of marijuana and its extracts can ease the symptoms of lymphoma and improve one’s overall quality of life.

It is during deep sleep that the body and brain undergo regenerative [10] and restorative processes. Cannabis encourages deeper sleeps for longer periods. Getting good sleep is crucial to maintaining a healthy lymphatic and immune system. Decreased sleep is linked [11] to poor immune function, which must be avoided at all costs by lymphoma patients.

Besides cell growth, CBD reduced glioma cell migration [43] and invasiveness in a Boyden chamber test [39], at concentrations lower than those required to inhibit cell proliferation. The CBD anti-migratory effect was not antagonized by the selective cannabinoid receptor antagonists or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or Gi/o protein-coupled receptors.

Surprisingly, so far no study has investigated the effect of CBD on angiogenesis. Our data currently awaiting publication [58] demonstrated that CBD potently inhibited HUVE cells proliferation, migration and invasion through the induction of endothelial cell cytostasis without triggering apoptosis. Interestingly, CBD also affected endothelial cell differentiation into tubular capillaries as well as the outgrowth of capillary-like structures from HUVEC spheroids in vitro. In addition, the anti-angiogenic properties of CBD were demonstrated also in vivo, using a matrigel sponge model. These effects were associated with down-modulation of several molecules associated with angiogenesis, including MMP2, MMP9, uPA, endothelin-1, PDGF-AA and CXCL16.

Cannabinoids are currently used in cancer patients to palliate wasting, emesis and pain that often accompany cancer. A significant advancement in cannabinoid use in cancer treatment came from the discovery of a potential utility of these compounds for targeting and killing cancer cells. In 1975 Munson et al. [17] demonstrated that the administration of Δ 9 -THC, Δ 8 -THC and cannabinol inhibited the growth of Lewis lung adenocarcinoma cells in vitro as well as in vivo after oral administration in mice. The interest in anticarcinogenic properties of cannabinoids was even renewed after the discovery of the eCB system and the cloning of the specific cannabinoid receptors. Since then, several cannabinoids have been shown to exert anti-proliferative and pro-apoptotic effects in various cancer types (lung, glioma, thyroid, lymphoma, skin, pancreas, uterus, breast, prostate and colorectal carcinoma) both in vitro and in vivo[18–26]. Moreover, other antitumourigenic mechanisms of cannabinoids are currently emerging, showing their ability to interfere with tumour neovascularization, cancer cell migration, adhesion, invasion and metastasization [27].

CBD and lung cancer

Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.

Some of the potential biological targets of CBD

As a whole this work highlights the presence of a complex balance between autophagy and mitochondria-mediated apoptosis in CBD-induced breast cancer cell death and strengthens the idea that CBD can be considered as an alternative agent for breast cancer therapy. Figure 3 shows a schematic representation of the signalling pathways associated with the effect of CBD in breast cancer cell proliferation and invasion.

Over the past years, several lines of evidence support an antitumourigenic effect of cannabinoids including Δ 9 -tetrahydrocannabinol (Δ 9 -THC), synthetic agonists, endocannabinoids and endocannabinoid transport or degradation inhibitors. Indeed, cannabinoids possess anti-proliferative and pro-apoptotic effects and they are known to interfere with tumour neovascularization, cancer cell migration, adhesion, invasion and metastasization. However, the clinical use of Δ 9 -THC and additional cannabinoid agonists is often limited by their unwanted psychoactive side effects, and for this reason interest in non-psychoactive cannabinoid compounds with structural affinity for Δ 9 -THC, such as cannabidiol (CBD), has substantially increased in recent years. The present review will focus on the efficacy of CBD in the modulation of different steps of tumourigenesis in several types of cancer and highlights the importance of exploring CBD/CBD analogues as alternative therapeutic agents.

Yes. Epidiolex. It was originally approved in 2018 for the treatment of two conditions, both related to epilepsy: Lennox-Gastaut syndrome and Dravet syndrome. But aside from Epidiolex, no CBD product has been approved by the FDA for any other medical purpose.

Have any CBD-oil derived products been approved by the U.S. Food and Drug Administration (FDA) to treat cancer, its symptoms, or the side effects caused by its treatment?

Does CBD oil have any side effects?

Marijuana and hemp are both varieties of the cannabis sativa plant. Both contain cannabidiol (CBD) and tetrahydrocannabinol (THC) — the two most-common, known active ingredients.

There’s still a lot to learn. So always let your health care team know if you are using CBD oil. That way, we can make sure nothing interacts adversely with your cancer treatments or other medications.