CBD Oil And Vyvanse

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When you take CBD alongside certain medications, it can trigger negative drug interactions. Here we explain what drugs shouldn’t be taken with CBD — and when to consult your doctor if you’re not sure about the potential interactions. Your complete guide to all things CBD and ADHD, according to the experts. CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects. Find out if they’re safe to use together.

CBD Drug Interactions – Mixing Cannabidiol and Medications

Are you worried about potential CBD-drug interactions? In this article, we explain the mechanism behind drug metabolism and how CBD may interfere with it.

The range of therapeutic properties offered by CBD (cannabidiol) has spurred its popularity in recent years. This natural compound is known to relieve a host of symptoms, allowing for safer and more effective management of different health conditions.

And unlike THC (tetrahydrocannabinol), CBD is non-intoxicating, so it won’t get you high.

CBD can assist in the treatment of anxiety disorders and depression, inflammation and pain, neurodegeneration, seizure disorders, sleep deprivation, metabolic conditions, neuropathy, migraines, inflammatory bowel disease, and more.

Considering CBD has so many potential health benefits, you may start wondering if it can interact with certain medications used to address the same symptoms — and whether you should or shouldn’t take these drugs with CBD.

Below you’ll find the dos and don’ts of using CBD along with medications.

Let’s start with the don’ts.

What Drugs Should Not Be Taken with CBD

Studies from the Indiana University Department of Medicine have provided a list of pharmaceutical drugs and medications which shouldn’t be taken with CBD.

The list below covers all groups of drugs that can negatively interact with CBD oil.

  • Angiotension II Blockers
  • Antiarrhythmics
  • Antibiotics
  • Antidepressants
  • Anticonvulsants / Anti-Seizure Medications
  • Antihistamines
  • Antipsychotics
  • Anesthetics
  • Beta-Blockers
  • Benzodiazepines
  • Calcium Channel Blockers
  • HIV Antivirals
  • HMG CoA Reductase Inhibitors (Statins)
  • Immune Modulators
  • Non-Steroidal Anti-Inflammatory Drugs
  • Oral Hypoglycemic Agents
  • Proton-Pump Inhibitors (PPIs)
  • Prokinetics
  • Steroids and Corticosteroids
  • Sulfonylureas

There’s also a group of drugs called “prodrugs” that first need to be processed into their therapeutic compounds instead of being therapeutic compounds on their own. In plain English, the inactive compound is consumed, and once in the body, it turns into the active compound.

If this mechanism is dependant on the CYP450 system (more on that later), a drug interaction can lead to insufficient concentrations of the therapeutic agent in the bloodstream — reducing its potency.

CBD Interaction with Drugs & Medications

This section covers the most common interactions between CBD and medications. If you take any of the substances listed below, make sure to consult your doctor before buying CBD oil.

CBD and Ibuprofen Interaction

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), meaning it can produce similar benefits to CBD in terms of inflammation and pain relief. Previously we’ve mentioned that NSAIDs interact with CBD, which may raise concerns about potential negative interactions between CBD oil and Ibuprofen.

According to a study from the Journal of Neurology Research, there have been no reported interactions between CBD and ibuprofen, although it doesn’t mean they do not exist. Health experts suggest that potential interactions may be dosage-dependent. If a certain dosage threshold is breached, CBD and NSAIDs like Ibuprofen can lead to unforeseen and potentially severe nervous system pathology.

CBD and Adderall Interaction

A 2020 study found that higher doses of medical cannabis led to a decreased use of ADHD medication in adults. Products containing a higher concentration of CBD were linked to lower ADHD scores. This means that CBD can interact with ADHD meds, decreasing their efficacy while providing more pronounced benefits. The potential side effects of interactions between CBD and Adderall may lead to decreased appetite.

CBD and Lamictal Interaction

Using medical cannabis and Lamictal may increase side effects such as dizziness, confusion, drowsiness, and difficulty concentrating. Elderly consumers may also experience impairment in judgment. That being said, none of these side effects were proven to result from CBD use per se. When it comes to interactions between CBD and Lamictal, it can make the medication more or less effective, depending on the dosage.

CBD Oil and Antibiotics

There is no known interaction between CBD and antibiotics, although these interactions may occur if an antibiotic is metabolized through the cytochrome P450 enzyme system. Some studies indicate that taking CBD and antibiotics together may amplify the effects of one another without any negative side effects. However, more research is needed to confirm these findings on a larger scale.

CBD Oil and Omeprazole

CBD can inhibit the enzymes that are targeted by omeprazole and other Proton Pump Inhibitors (PPIs). Taking CBD with certain heartburn medications can increase the risk of diarrhea.

CBD and Thyroid Medications

Some people report mild nausea when taking CBD oil together with their thyroid medications. Since both substances are processed by the CYP450 enzyme system, taking CBD with a thyroid medication may cause hyperthyroidism because more thyroxine would be secreted than the body could metabolize.

CBD and Lisinopril

CBD can temporarily lower blood pressure, so taking it alongside medications like Lisinopril might reduce it even more, making you feel lethargic and weak. Always consult your doctor before adding CBD to your routine if you use anti-hypertension meds.

CBD and Prednisone

Since both CBD and corticosteroids are potent inhibitors of the CYP450 enzyme system, concomitant use may increase the risk of systemic side effects from corticosteroid use due to decreased glucocorticoid clearance. Corticosteroids like prednisolone and hydrocortisone should never be taken with CBD.

How Drugs Interact: Understanding Drug Metabolism

Metabolism can refer to how your body uses energy for weight management, or the way drugs are metabolized in your body.

The former is known as the basal metabolic rate, or in simple terms, the number of calories a person needs to maintain healthy body functions while at rest.

The latter is very different from the basal metabolic rate. Drug metabolism refers to how a substance is processed and used by the body — with the majority of this processing happening in the liver.

Scientists call it the ‘first-pass effect’ or ‘first-pass metabolism.’

Using straightforward terms, when you take a medication, it is broken down in the liver into its active compounds so that the body can use them. Just like carbohydrates are broken down into sugars, fats into triglycerides, and proteins into amino acids — drugs break down into their individual ingredients.

From there, they are controlled by specific enzymes, which transform these compounds into metabolites. These metabolites then influence different processes in your body and are flushed with urine once used up.

How Is CBD Metabolized?

Drug metabolism determines the rate at which the body processes medications and other therapeutic compounds into their individual metabolites and how long they can stay in your system.

When you take CBD in the form of an oil, capsule, or gummy, it has to pass through your gut, where it is released into the bloodstream. From then, they travel through the bloodstream to the liver, where it absorbs through the hepatic portal. The liver breaks CBD down into its metabolites using enzymes, after which it can circulate throughout the body in the bloodstream again.

What Is the Cytochrome P450 System?

Aside from breaking compounds down into metabolites, the liver also detoxifies and excretes foreign substances and other types of toxic compounds. This can happen through a system of enzymes referred to as the Cytochrome P450 (CYP450). These enzymes contain heme as a cofactor to convert cannabinoids into more water-soluble molecules, increasing their absorption and efficacy.

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Researchers estimate that the CYP450 system is responsible for metabolizing 60% of any drugs out there. And interestingly, doctors and pharmacists use this system to understand, evaluate, and predict the benefits of the drug and potential side effects based on their dosages.

However, certain compounds have the ability to compromise the CYP system’s functioning, negatively affecting the metabolism of certain medications. Once these interactions occur, the drugs can be metabolized faster or slower than normal.

CBD And the Cytochrome P450 System

As mentioned earlier, CBD can interact directly with the CYP450 system in the liver. According to preclinical studies, CBD binds to the site where the enzyme activity occurs, competing with other compounds and thus preventing this system from breaking down other substances.

This inhibitory effect on the CYP450 enzymes mainly depends on how much CBD a person takes, their unique physiology, and the type of CBD used (e.g., full-spectrum CBD vs. CBD isolate). The dosage determines the strength used by the CBD to bind to the active site of the metabolic enzymes. The tighter the bond, the more competitive inhibition.

Contraindications for Taking CBD with Medications

The mechanism behind CBD’s health benefits proves that it’s not a biologically inert compound. Instead, the pharmacokinetics and pharmacodynamics of CBD are complex and similar to any other medication. Therefore, it has the potential to compromise the metabolism of certain medications.

Any therapeutic substance that relies on the CYP450 system can be potentially affected by CBD. A common indicator for such interaction is when your medication has a grapefruit warning on the bottle. However, this is by no means a solid point of reference, and you should always check with your doctor and pharmacist before taking the two compounds together.

Why You Should Always Consult Your Doctor First

The list of drugs that we’ve mentioned above is by no means definite and doesn’t include all the pharmaceutical substances that may interact with CBD. Similarly, not all the medication from these categories will necessarily cause an interaction — as is the case for antibiotics and Ibuprofen.

A consultation with a doctor experienced in CBD and cannabis use can help you establish the right routine for your medications and supplements to avoid potentially negative interactions. Some compounds work synergistically with CBD, so asking your doctor can help you maximize the effect of your treatment.

Not to mention that the doctor can guide you on finding the optimal dosage for yourself.

Key Takeaways on CBD Drug Interactions

The safety profile of CBD has been acknowledged by major health agencies, such as the World Health Organization (WHO), showing that it’s well-tolerated by animals and humans and rarely produces any dangerous side effects.

CBD also has a profound impact on an array of systems, which explains its therapeutic versatility. That being said, this versatility is also the reason why CBD interacts with so many prescription meds and over-the-counter (OTC) PRODUCTS.

Again, if you’re not sure if CBD will interact with the medication that you might be taking, a consultation with a health professional will not harm — unlike trying to figure out these interactions on your own.

Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

Can CBD help with ADHD symptoms?

Your complete guide to all things CBD and ADHD, according to the experts.

Disclaimer: you should always talk to your physician or pharmacist before trying anything new that may affect your health (substances, medication). This guide is simply for reference, and is NOT intended to be a substitution for professional medical advice. Additionally, please note that this article was written from the perspective of a USA citizen. Check with your local cannabis laws for more information on CBD products in your area.

So, CBD is having a moment.

It’s on Instagram ads, I hear it on podcasts. even my local grocery store sells CBD products! But what the heck is CBD? And can it treat or help with ADHD symptoms?

This CBD and ADHD guide is here to give you the scoop.

Everything you need to know about CBD

What does CBD stand for?

CBD stands for cannabidiol, an active ingredient in the marijuana plant. It’s typically made from hemp, which is a non-intoxicating variety of cannabis.

Unlike the main active ingredient in marijuana, THC (Tetrahydrocannabinol), CBD is non-psychoactive, which means it doesn’t get you high. It’s also known for treating pain and anxiety.

How do you take CBD?

Cannabidiol oil is available in a variety of forms:

  • Ingestion: eating products containing CBD oil, such as gummies, candies, or tinctures
  • Sublingual: putting the oil underneath your tongue
  • Inhalation: smoking hemp or marijuana with high CBD content
  • Topical: applying CBD lotions to your skin

If and when you decide to purchase CBD, make sure you know exactly what you’re buying.

Some CBD products also contain THC, which means it can have psychoactive effects. As a general rule, cannabis products with a ratio on their packaging (1:1, 20:1, etc.) contain both compounds. The first number is CBD and the second is THC. So, a 1:1 ratio means the product contains equal amounts of THC and CBD.

CBD and ADHD

How does CBD affect ADHD symptoms?

Much of the medically-reviewed research covers general marijuana use, and not cannabidiol specifically.

A 2017 clinical data review published in Cannabis and Cannabinoid Research found promising positive effects of the compound.

The review confirmed that cannabidiol is indeed safe, with fewer adverse side effects than comparable medications. Though the review focused on epilepsy and psychosis, the safety and efficacy findings can apply to all uses.

A 2014 study compared the executive functioning of neurotypical adults versus those with ADHD who had or had not recently used cannabis. (Keep in mind that this study was about general cannabis, and didn’t specifically look at CBD by itself.)

The study concluded that while ADHDers scored lower on executive functioning than those without ADHD (duh, you already knew that), cannabis did not have a significant effect on that functioning.

Does cannabis make ADHD symptoms worse?

While the data can’t speak for everyone, the 2014 study mentioned above did answer this question with a resounding “no”. However, researchers found that early cannabis use (before age 16) can reduce the capacity for executive functioning, but more research needs to be done in order to determine specifics.

So, does cannabis improve ADHD symptoms?

Now, hold on — I didn’t say that! Let’s look at another study that was inspired by ADHDers who self-medicate with cannabis. Researchers investigated possible benefits of cannabis for ADHD and published their findings in European Neuropsychopharmacology. Again, this study wasn’t CBD-specific, but instead investigated general cannabis use. The results of the small study (30 participants) ranged from positive to neutral. ADHDers using cannabis scored slightly better on cognitive performance and activity levels than the placebo group.

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Participants also demonstrated small but promising improvements in:

Research estimates that 25-50% of ADHDers have an anxiety disorder; lucky for us, there’s some evidence that cannabidiol can relieve anxiety. Some people with ADHD praise CBD for its ability to calm their racing anxious minds, which allows them to relax and focus.

You can find resources on using CBD for anxiety relief here and here.

CBD side effects

Cannabidiol is generally considered safe, but some users report undesired side effects, such as:

  • Nausea
  • Diarrhea
  • Drowsiness
  • Dry mouth
  • Feeling lightheaded

In rare instances, CBD can cause liver damage. Because of this, you should proceed with extreme caution if you have liver disease, risk factors for liver disease, or are taking medication that can cause liver problems.

CBD and medication

If you take prescription medications, check with your doctor or pharmacist before trying CBD. It’s always good to consult with your doctor, but I’m also empathetic to fears about being labeled a “drug user” or being otherwise judged by physicians for taking CBD. If you have a good relationship with—and trust—your doctor, I recommend full honesty.

It’s also important to remember that cannabis products aren’t strictly regulated in the same way prescription drugs are. You should only purchase products from trusted, vetted, authorized retailers.

General medication interactions

Here are some common prescription drugs that can potentially interact with CBD. This list isn’t exhaustive and to ask a professional about drug interactions.

Some drugs known to interact with CBD:

  • Warfarin: commonly prescribed blood thinner
  • Amiodarone: heart rhythm medication
  • Levothyroxine: thyroid medication
  • Seizure medication: valproate, clobazam, lamotrigine
  • Blood pressure drugs: large doses of cannabidiol may interact
  • Metformin and heartburn drugs like Prilosec: increase risk of diarrhea

CBD and ADHD medication

Unfortunately, there isn’t a ton of research on the interaction with ADHD medications. I did find at least one source that said CBD may worsen the decreased appetite that’s common when taking stimulants. There also appears to be a small risk of decreased efficacy of ADHD medication when taking cannabidiol.

The grapefruit rule

One major caveat to keep in mind is the grapefruit rule: if your medication interacts with grapefruit, you shouldn’t take CBD with it.

Here’s a resource about cannabidiol and medications that interact with grapefruit, but you should check if your specific medication brands apply to the grapefruit rule. I found evidence of some positive interactions between CBD and stimulants, including reduced muscle tension and anxiety.

To read more about CBD and ADHD, check out this resource.

Stimulants and nonstimulants

Below is everything we could find on common ADHD meds (both stimulant and nonstimulant) and their potential for CBD interaction. This list isn’t exhaustive!

  • Adderall: Potential appetite loss and reduced efficacy
  • Ritalin: Potential interactions at extremely high CBD doses (hundreds to thousands of milligrams); common therapeutic doses are well below this threshold
  • Dexedrine: Potential appetite loss and reduced efficacy
  • Concerta, Vyvanse: Cannabidiol may prevent proper processing of meds and decrease efficacy
  • Wellbutrin: Potential interaction; extent unknown. CBD might increase Wellbutrin’s side effects and/or decrease effectiveness

Is CBD legal?

To paraphrase The Simpsons’ Reverend Lovejoy, “Short answer yes, with an if; long answer no, with a but.”

Federally, all cannabis products are illegal and CBD isn’t FDA-approved (Food and Drug Administration). But 36 states have legalized medical marijuana, and many others legalized recreational use. If you’re in one of those states, CBD is indeed legal and available at dispensaries and other authorized retailers. CBD can be derived from either hemp or marijuana.

Hemp is legal in the USA

Hemp is legal in all states because federal law requires hemp products contain less than 0.3% THC. If marijuana (medical or recreational) is not legal where you live, then products made directly from marijuana are also illegal.

If you’re outside of the USA, I suggest looking up your local marijuana laws.

Should I treat my ADHD with CBD?

First, I want to remind you that I’m not a doctor – simply a woman with ADHD who did a bunch of research about CBD.

As suggested above, you should always check with your doctor before starting any new substance or medication. You could even send them the studies I linked above so you’re both on the same page about current research.

Let’s say you’ve talked to your doc and they approve of you trying CBD. So — should you go for it? That depends on several things.

I take CBD daily for chronic pain; the pain relief helps me focus on work instead of my pain. So in that way, it benefits my ADHD. However, I can’t say CBD specifically helps ADHD-related behaviors. It doesn’t make my symptoms worse, but it’s not a go-to for treatment.

Of course, this is just one person’s experience and shouldn’t influence your own health decisions! But as a daily user, I’d be remiss if I didn’t acknowledge that.

Here are some circumstance where I think it’d be safe to try CBD:
  • It’s legal where you live and easy to obtain
  • You’ve had previous positive experiences with cannabis
  • Your doctor approves
. and some instances where I think you should not try CBD:
  • CBD isn’t legal for recreational use in your state or country
  • You have liver disease or are at risk for liver disease
  • You’ve had previous adverse experiences with cannabis or CBD
  • Your doctor advised against it for health reasons

Final thoughts

I hope this humble ADHD and CBD guide has given you some answers and helpful info. Whether you’re already a CBD aficionado, are curious to try it, or know it’s not for you, I hope you find some relief — from CBD or from whatever works for you.

Looking for support?

Inflow can help you thrive with ADHD and reach your full potential. Start your journey now by taking our quiz.

Ash Fisher is a Portland-based writer, performer and corgi mom. Check out her writing at ashfisherhaha.com.

Does CBD Interact With Lisdexamfetamine (Vyvanse)?

CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects.

The risk of this interaction is mild to moderate.

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Lisdexamfetamine (Vyvanse) is a neuro-stimulant used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It belongs to the amphetamine family of drugs.

Cannabidiol or CBD , a cannabinoid with many health-promoting properties, may behave antagonistically with or slow down the metabolism of lisdexamfetamine and cause side effects.

Are the two safe to take together?

Table of Contents

Does CBD Interact With Lisdexamfetamine (Vyvanse)?

Yes, CBD is likely to interact with Vyvanse — however, the severity of this interaction is low and unlikely to result in any lasting side effects.

There are two primary ways CBD can interact with stimulant drugs like lisdexamfetamine (Vyvanse).

1. Decreased Effects (Antagonistic Interaction)

CBD may counteract some of the stimulating effects of Vyvanse — preventing it from doing its job effectively.

Antagonistic interaction occurs when two drugs act in opposite ways. If taken together, one drug could interfere and even stop the actions of the other drug, causing the second drug to become less effective.

Lisdexamfetamine is a stimulant drug that enhances brain activities such as awareness, wakefulness, emotional regulation, attention, learning, and memory.

In contrast, CBD is a neuromodulator that exerts its effects on the central nervous system (CNS) via multiple pathways that are not yet fully understood. CBD is used as an anticonvulsant and anxiolytic. These effects may happen through its actions on endogenous systems such as neuronal inhibition and intracellular calcium modulation.

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Because of their opposite effects, they are likely to cancel each other out, and CBD may reduce the activity and efficacy of lisdexamfetamine.

2. Slowed Elimination (Metabolic Inhibitor)

CBD may interfere with the body’s ability to metabolize Vyvanse — leading to elevated levels. This could lead to an increased risk of side effects from the medication.

Drugs are metabolized in the body due to the actions of the cytochrome P450 class of enzymes. When two medications that need similar enzymes for metabolism are taken together, they compete for the enzyme. This action could result in slowing down the metabolism of both drugs.

Lisdexamfetamine is extensively metabolized and eliminated by the CYP2D6 enzyme. While CYP2D6 also metabolizes CBD, CYP3A4 is the major enzyme responsible for its metabolism. However, CBD has inhibitory effects on CYP2D6, which can slow down the metabolism of lisdexamfetamine. This could cause lisdexamfetamine to accumulate within the body and cause unintentional side effects.

Other Names for Lisdexamfetamine

Lisdexamfetamine is sold under different names. All of them have the same base ingredient and have similar possible interactions.

Other names for lisdexamfetamine include:

Similar Medications: CBD & Stimulants

Lisdexamfetamine (Vyvanse) is a stimulant. CBD and stimulants all share similar risks for interaction and side effects.

Some of the medications that share similar risks when combined with CBD are:

  • Amphetamine (Adderall, Adzenys ER, Mydayis)
  • DextroamphetamineSulfate (Zenzedi, Dexedrine)
  • Methylphenidate (Ritalin)
  • Atomoxetine (Strattera)
  • Modafinil (Provigil, Nuvigil)

Is It Safe to Take CBD & Lisdexamfetamine (Vyvanse) Together?

Yes, CBD is unlikely to pose any danger when taken with Vyvanse (when used in responsible doses).

However, CBD may negate some of the beneficial effects of the drug, causing it to be insufficient for managing the symptoms it was prescribed for.

Because the conditions Vyvanse is used to treat aren’t life-threatening, there’s a low chance of this effect resulting in any serious consequences.

The main indication for lisdexamfetamine is ADHD, and taking the two drugs together may make symptoms of ADHD worse due to decreased efficacy of lisdexamfetamine.

Always consult your prescribing physician first before you start these drugs, and never adjust the dose or stop taking Vyvanse on your own.

Is CBD a Viable Alternative to Lisdexamfetamine (Vyvanse)?

CBD is not considered a viable alternative to lisdexamfetamine (Vyvanse).

However, there are a few conditions where CBD may work for which lisdexamfetamine is indicated or even work as an adjunct to it.

Researchers had initially believed that CBD could worsen the symptoms of ADHD, but studies have not found any evidence to support this. In fact, some research shows positive results using CBD for ADHD [1].

Depending on the severity of the problem, maybe CBD could be enough to help, but it’s always best to talk to your doctor before changing or adjusting medications.

CBD may also help patients who binge eat but, again, the research lacks anything conclusive [2].

One of the most significant differences between CBD and lisdexamfetamine is that the latter is more likely to result in dependence and withdrawal symptoms. Therefore, there is a chance that lisdexamfetamine can be misused and overdosed.

What Is Lisdexamfetamine (Vyvanse)?

Lisdexamfetamine (Vyvanse) is a derivative of the drug amphetamine and belongs to a class called central nervous system stimulant.

Vyvanse is the brand name of the drug lisdexamfetamine. It is a prodrug of the psychostimulant d-amphetamine.

It’s used mainly to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It’s a prescription medicine approved by the FDA that works by increasing the production and decreasing the metabolism of the neurotransmitters like dopamine, serotonin, and norepinephrine.

Lisdexamfetamine (Vyvanse) Specs:

Drug Name Lisdexamfetamine
Trade Name Vyvanse, Tyvense, Elvanse
Classification Central nervous system stimulant
CYP Metabolism CYP2D6 enzyme
Interaction With CBD Antagonistic and Metabolic Inhibition
Risk of Interaction Mild

What Does Lisdexamfetamine (Vyvanse) Do?

Lisdexamfetamine (Vyvanse) can increase the attention span and decrease restlessness in children and adults with ADHD.

It’s also used for binge-eating disorders because of its appetite suppressant qualities.

Lisdexamfetamine for ADHD

ADHD is a disorder of the brain where the person tends to lack the ability to concentrate, has difficulty controlling impulsive behaviors, and is overly active.

The exact mechanism of ADHD is not completely understood. However, it is linked to genetics, exposure to environmental risks, and toxins during pregnancy, among other things.

People with ADHD may have a higher concentration of dopamine transporters in the brain. This means these transporters remove dopamine from the brain too fast, causing a decreased level of dopamine in the brain. There also tend to be low levels of serotonin and norepinephrine in the brain in those with ADHD.

Once consumed, lisdexamfetamine turns into dextroamphetamine and L-lysine. This drug has two optical isomers called trace-amine associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2). It can enter monoamine neurons and release monoamine neurotransmitters like dopamine, serotonin, and norepinephrine from their storage places in presynaptic neurons.

These neurotransmitters help in alertness and increase and maintain concentration and motivation. It can also prevent the reuptake of these neurotransmitters from the synaptic cleft but does not bind to the sites of the reuptake of norepinephrine and dopamine.

Lisdexamfetamine for Binge Eating

The exact action of lisdexamfetamine (Vyvanse) on binge eating disorders is unknown. In binge eating disorders, food may trigger the brain to make more dopamine, the hormone that makes us feel pleasure.

It’s possible that lisdexamfetamine raises the dopamine levels in the brain and sustains it enough so that the person does not consume more food than necessary. However, this has not been proven yet.

Lisdexamfetamine may have less abuse potential compared to other amphetamines but can still cause dependence.

Side Effects of Lisdexamfetamine (Vyvanse)

Symptoms vary from minor to severe. It’s good to know what can happen so you can inform your doctor if you experience any.

  • Loss of appetite
  • Diarrhea
  • Insomnia
  • Irritability
  • Headache
  • Stomach upset
  • Seizure
  • Rash
  • Increased blood pressure
  • Tremor
  • Tics
  • Vomiting
  • Increased heart rate
  • Blurred vision
  • Fatigue
  • Nausea
  • Mania
  • Psychosis
  • Hypersensitivity
  • High possibility of substance abuse

If you’re using lisdexamfetamine and suspect you’re becoming dependant on it, speak to your doctor immediately. They can help you reduce the dose gradually to avoid withdrawal.

Lisdexamfetamine withdrawal symptoms include:

  • Tremors
  • Sweating
  • Insomnia
  • Irritability
  • Anxiety
  • Depression

If you want to stop taking lisdexamfetamine and shift to CBD, you should talk to your doctor first. They may recommend slowly tapering this drug to avoid or to reduce the withdrawal symptoms.

Key Takeaways: Is It Safe to Take Lisdexamfetamine (Vyvanse) With CBD?

CBD can decrease the effects of lisdexamfetamine (Vyvanse) and even slow down its metabolism from the body, causing more unintended side effects.

This interaction is considered mild and low risk — but caution is still advised.

If you experience any adverse effects after taking CBD with Vyvanse, seek medical attention immediately.

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