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cbd oil for autoimmune

Inflammation is the trigger of many illnesses, and autoimmunity falls into that bracket. Medical researchers have broadly described the anti-inflammatory properties of CBD and other cannabis ingredients. Regulating inflammation reduces the likelihood of an autoimmune attack. Cannabis therapies are known to assist people with autoimmune conditions by curbing inflammation with little to no adverse reactions. According to preclinical studies, CBD can attenuate autoimmune response on top of decreasing the gene transcription that promotes inflammation.

However, immunosuppressants can weaken the immune system over time, making it more susceptible to infections, which can further deteriorate an autoimmune disease.

Fortunately, since cannabinoid receptors aren’t found in the brain stem area that controls respiratory function, it’s impossible to fatally overdose on CBD.

CBD Dosage for Autoimmune Diseases

The reason why people are turning to CBD for autoimmune diseases lies in its high safety profile. Unlike conventional immunosuppressants, CBD doesn’t shut down the immune system. Instead, it reduces inflammation while modulating the communication between the system’s cells. In other words, CBD helps the body fix the immune response without harming it — something which pharmaceutical medications fail to achieve.

Autoimmunity is both difficult to diagnose and treat. The reason why the self-attack happens is still unknown. Some researchers argue that autoimmunity derives from hereditary factors, while others turn to events like parasites, infection, traumatic experiences, and leaky gut syndrome. When it comes to treatment options, doctors typically go with immunosuppressants, which — in simple terms — shut down the immune system to prevent the auto-aggressive response.

CBD has been found to modulate the immune system in autoimmunity disease models. CBD also suppresses immune system memory and slows down T-cell production, meaning that it could reduce the likelihood of future autoimmune flare-ups.

The general recommendation is to start low and slow. Take the minimum dose based on your weight — 2–6 mg per every 10 pounds of your body weight — and observe the effects over the course of one week. Adjust the dosage as needed and continue for another week. Once you’ve found the sweet spot, you can lock that dosage in and stick to it, as people don’t build a tolerance to CBD.

Santamaria, Pere.”Cytokines and Chemokines in Autoimmune Disease: An Overview”. Madame Curie Bioscience Database

Ignatowska-Jankowska B, et all. “Cannabidiol-induced lymphopenia does not involve NKT and NK cells”. J Physiol Pharmacol. 2009

While advancements in science have enabled a greater understanding of our health, getting to the root cause of a chronic disease can be challenging. Autoimmune conditions are an area of medicine that remain largely misunderstood. Presently, there are more than 80 registered autoimmune disorders, affecting various parts of the body. More conditions may also turn out to be autoimmune related.

Decreasing inflammation

In general, immunosuppressive therapy is incredibly expensive and not always effective. The aim should be to modulate the immune system and bring it back into balance, not to turn it off completely.

Someone with an autoimmune disease may consider cannabinoid therapies for their ability to decrease inflammation, modulate the immune system, and help to bring the system back into balance.

There has been some preclinical investigation focusing on the role of particular cannabinoids in AI disease models. CBD has been found to modulate the immune system instead of suppressing it. Cannabidiol also slows down T-cell production and suppresses immune system memory, meaning that CBD could cut down on the likelihood of future autoimmune attacks. CBD has also been found to increase the expression of genes that deal with oxidative stress, which may reduce cell damage from autoimmune attacks. As for THC, this cannabinoid is immunosuppressive only at very high doses. In low doses can be helpful as an analgesic and anti-inflammatory. Its ability to activate CB2 receptors may down regulate T cell function and decrease the harmful effects of immune cells.

Yeshurun, M, et al. “Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study” Biol Blood Marrow Transplant. 2015

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Hemp is gaining popularity on a daily basis. This controversial plant, which many still associate with illegal substances, carries a veritable treasure trove of substances that have a soothing effect on a variety of problems. It is also becoming increasingly popular in the field of medicinal uses. Numerous clinical studies and scientific papers reported positive results in therapies involving cannabis resin. The best-known ingredient of cannabis resin is the CBD cannabinoid that proved effective in the field of various auto-immune disorders, Alzheimer’s and Parkinson’s disease. It also recorded positive effects with Crohn’s disease, insomnia, diabetes, depression, and several others. CBD oil is also effective in the field of skin problems, calming autoimmune reactions on the skin and reducing sebum secretion from the sebaceous glands.

Cannabinoids are messengers

CBD or cannabidiol is a compound found in hemp leaves and flowers whose production and use is completely legal in Slovenia. CBD has many beneficial effects on the human organism and does not cause intoxication – it has no psychoactive effects on a person. CBD is a cannabinoid molecule very similar to the molecule that can be found in the human body, responsible for communication between cells.

Cannabinoid molecules, named endocannabinoids, form in the human body as well as all other vertebrates and owe their name to chemical structure similarities they share with cannabinoids in hemp. The endocannabinoids in our bodies function as intercellular lipid messengers that are released from one cell membrane, activating the receptors on the membrane of another cell. Their signals are retrograde because they move, or more accurately, exchange materials and communicate opposite to the usual direction of the intercellular signals. This behavior is what makes them an active substance, lowering the secretion of insulin in the bloodstream, reducing pain and temperature and calming the immune system.

Our body is capable of producing the message-transmitting cannabinoids on its own, however, when our body is sick, tired or under severe stress, the production stops and we no longer produce our own cannabinoids. In such cases, we can assist with an input of phytocannabinoids. These can be found in hemp, with CBD being the most researched one. Hemp cannabinoids bind to the same receptors as cannabinoids produced in our own bodies. This makes the body recognize and accept them as its own. Cannabinoid receptors are also found in skin cells, which enables CBD to function effectively and locally through the skin as well.

3. Abood ME, Sorensen RG, Stella N, eds. endoCANNABINOIDS. New York, New York, USA: Springer Science+Business Media New York; 2013.