Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures. The maximal load and work-to-failure, but not the stiffness, of femurs from rats given a mixture of CBD and Δ(9) -tetrahydrocannabinol (THC) for 8 weeks were markedly increased by CBD. This effect is not shared by THC (the psychoactive component of cannabis), but THC potentiates the CBD stimulated work-to-failure at 6 weeks postfracture followed by attenuation of the CBD effect at 8 weeks. Using micro-computed tomography (μCT), the fracture callus size was transiently reduced by either CBD or THC 4 weeks after fracture but reached control level after 6 and 8 weeks. The callus material density was unaffected by CBD and/or THC. By contrast, CBD stimulated mRNA expression of Plod1 in primary osteoblast cultures, encoding an enzyme that catalyzes lysine hydroxylation, which is in turn involved in collagen crosslinking and stabilization. Using Fourier transform infrared (FTIR) spectroscopy we confirmed the increase in collagen crosslink ratio by CBD, which is likely to contribute to the improved biomechanical properties of the fracture callus. Taken together, these data show that CBD leads to improvement in fracture healing and demonstrate the critical mechanical role of collagen crosslinking enzymes.
Keywords: CANNABIDIOL; COLLAGEN CROSSLINKING; FRACTURE HEALING; FTIR; LYSYL HYDROXYLASE; μCT.
by Sydney Lupkin, Reporter, VICE News/MedPage Today July 23, 2015
A new study claims that a component in cannabis may help heal broken bones, but that doesn’t mean you should smoke a joint the next time you find yourself in a cast or on crutches.
— Forget the headlines you read. Here’s what you should know.
“Whether it translates to humans is unclear,” Glatter said. “It’s going to require much more work with multiple studies . That said, it’s encouraging.”
Robert Glatter, MD, who directs the emergency sports medicine program at Lenox Hill Hospital in New York City, expressed similar sentiments.
But lead study author Yankel Gabet, DMD, PhD, of Tel Aviv University in Israel, said it’s not clear how CBD heals bones in rats, let alone whether it would work in humans.
Marijuana has been a controversial treatment among medical professionals. Recently, a study published by The Journal of Bone and Mineral Research suggests that cannabinoid cannabidiol (CBD), the chemical in marijuana, could strengthen the bone and help heal fractures. According to an online interview Yankel Gabet, the researcher of the study, CBD is effective in developing more mineralization in the bone tissue in the animal model. “CBD alone is sufficiently effective in enhancing fracture healing.” Another gradient in marijuana is tetrahydrocannabionol (THC), which causes the marijuana high. Adding THC does not affect the healing of the bones.
However, marijuana is still not widely accepted for medical use due to its concerning psychoactive effect. CBD extracts alone, on the other hand, is used as an experimental treatment for the Dravet syndrome, a rare form of child epilepsy. There has been encouraging literature on CBD in suppressing seizures, inhibiting cancer metastasis, and soothing chronic pain. However more robust clinical human trials are needed. We look forward to following more research into potential beneficial effects of CBD including bone related diseases like osteoarthritis and fractures.
Cannabis (CBD) Cannabidiol Helps bone health and heals fractures… Research suggests.
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