Lymphoma can be a devastating disease and can go undetected until it's too late. CBD may be a viable option for your furry friend who is dealing with Lymphoma! Find out what you need to know here! CBD may be able to effectively manage the symptoms of canine lymphoma. Potentially inducing an appetite, decreasing pain, and reducing inflammation. Looking for alternatives to manage canine lymphoma? This article discusses CBD oil and how this product may help relieve your furry friend's lymphoma symptoms.
CBD Oil for Dogs with Lymphoma
Lymphoma can be a devastating disease and can go undetected until it’s too late. The availability of testing these days has made it more commonly diagnosed, but no one really knows where it comes from. In this article, we will discuss some things to do and how to recognize the signs your dog may have Lymphoma.
What is Lymphoma in dogs?
Lymphoma is a type of cancer that affects white blood cells. This type of cancer typically invades systems responsible for the immune system such as lymph nodes, spleen, and bone marrow.
What happens to dogs that have Lymphoma?
Lymphoma cells can easily travel around the body looking for another organ to attack. There are many things that can be done to help slow down the spread of these cells or even make them decrease in numbers. Seeing your local veterinarian to help you with treatment options for your dog is always recommended. While not everyone can afford chemotherapy there are many different options on treatment you and your veterinarian can discuss. The goal is to prolong your dog’s life while still maintaining high-quality health and happiness.
What you should look for?
If you think that your dog has lymphoma, the first thing that you will see is swollen lymph nodes. These swellings are usually not painful to the touch. Your dog has external lymph nodes under his chin, mid neck, armpits, groin area, and behind his knees. If you notice any swelling in these locations, take your dog to a veterinarian to have them check for possible lymphoma or even a different type of cancer.
There are also lymph nodes inside the body. If you notice any gastrointestinal signs such as vomiting or diarrhea this can be a sign of GI lymphoma. Lymphoma of the lungs can cause difficulty breathing or coughing. Just because your pet may be showing any of these symptoms it is important not to jump to conclusions as there are many different reasons why they have occurred and usually cancer is not as common. Your dog’s veterinarian can certainly determine through testing what the issue may be.
What causes lymphoma
While the exact cause of lymphoma is unknown some people think that it can be due to bacteria, viruses, or some kind of chemical exposure. Evidence shows that Lymphoma does have a genetic component to it. There are certain breeds of dogs that are more prone to Lymphoma such as Boxers, Golden Retrievers. The possibility of these genes likely stems from overbreeding and inbreeding to try to maintain pure bloodlines.
What are treatments to dog Lymphoma?
Most dogs who have lymphoma will respond to chemotherapy. The lymphatic system circulates throughout the body thus making it impossible to just remove the one enlarged nodule as it can affect everything. On a positive note the fact that the lymphatic system is linked together throughout the entire body it responds well to treatments like chemotherapy. Just as cancer can move throughout the body so can the treatment which helps lessen or even stop the spread of cancer to other systems.
While most people who think of chemotherapy think of that person they know or what they have seen on TV of people who are sick all the time and losing their hair. Dogs do not have the same response to chemotherapy as people. Dogs are not given extremely high dosages of the medications as people get. Veterinarian’s goals are to prolong life with good quality. While sometimes a dog may get sick and feel lethargic most the time they actually seem to feel much better after treatment. Sometimes veterinarians will see vomiting or diarrhea with dogs undergoing chemotherapy and will prescribe medicine to help get them through these unfortunate side-effects. If a dog is sick on the day that they are scheduled for chemotherapy usually the veterinarian will skip that dosage or reschedule them for a later date when they feel much better. Again, the point is to make them feel better, not worse. The goal isn’t to cure cancer but to simply stop the spread of it and prolong the animal’s life.
What are alternatives that will also help
Many people look for other options to help their dog once they get a cancer diagnosis. There are many things that you can give your dog to help shrink the tumor or even help with the side effects of the disease or chemotherapy.
CBD or cannabidiol has recently shown to help pets fight disease such as cancer, skin problems, help with arthritis and increase appetite. CBD is derived from the hemp plant and contains little to no THC. THC is the psychotropic part of the plant. CBD would be a great supplement to give your dog even if they are not fighting cancer as it still promotes overall health benefits.
CBD oil for dog lymphoma
CBD is a great supplement to give to your dog who has lymphoma. If they are undergoing chemotherapy, CBD will help decrease nausea and make them want to eat a little more which will help keep their energy up thus making them feel better while undergoing treatment.
How to find the best CBD oil for dogs
When looking for CBD oil making sure that the products have been tested by a 3 rd party and ensure that they actually contain what they say they contain. The CBD oil that you purchase should say where the hemp is grown and how it is processed. Make sure that this is sourced by a reputable place and contains exactly what it should.
Can CBD Oil Help Dogs with Lymphoma?
CBD oil has been thought to help our canine friends with lymphoma and manage chemotherapy symptoms or side effects.
What is canine lymphoma? What are the symptoms of it? How is it typically treated? How can CBD help? We are going to answer all of these questions for you in this article.
Understanding Lymphoma in Dogs
Lymphoma is a group of cancers that affect the lymphatic system, as the name implies. This can be found in both canines and humans alike. The lymphatic system is an incredibly important network that is responsible for influencing the immune system and some other bodily functions.
It works to impact physiological processes and interacts with many parts of the body. Lymphoma is not as contained as some other cancers we are familiar with, and it spreads throughout the body relatively quickly.
Dogs diagnosed with untreated lymphoma typically have a life expectancy of 4-6 weeks after diagnosis. Lymphoma infiltrates organs until the organ has no choice but to fail. It begins like many other canine cancers as just a solitary tumor; however, because the lymphatic system’s function is to spread fluid throughout the body to various organs, it is not likely to be lonely for long. For dogs on a treatment plan, the life expectancy is more along the lines of a few months, anywhere between 6-12, depending on how they are being treated.
The Lymphatic System
Lymphoma is a type of cancer that starts in the infection-fighting cells of the immune system known as lymphocytes. Lymph nodes, the spleen, appendix, tonsils, lymph vessels, and lymph fluid are all key elements of the lymphatic system. The lymphatic system is a part of your immune system and possesses many functions. The functions include maintaining body fluid levels, protecting you from harmful invaders, absorbing digestive tract fats, and removing cellular waste. Diseases and infections can affect the way it functions, preventing it from working properly.
The lymphatic system is a network of tubes found throughout the body. It is responsible for draining fluid, which is referred to as “lymph,” that has seeped out from blood vessels into your tissue, and it empties it back into the bloodstream through means of the lymph nodes.
Lymphocytes are a type of white blood cell found in the immune system. Lymphocytes possess killer cells naturally, which are called T cells and B cells. These are the main types of cells found in the lymph fluid.
When a dog (or person) develops lymphoma, their lymphocytes transform into abnormal cancer cells, growing quickly and uncontrollably. This will cause a compromised immune system, and when these cells make their way throughout the dog’s lymphatic system, they force themselves into lymph nodes and cause swelling.
While there are different forms of canine lymphoma, the most common type of lymphoma in dogs is referred to as multicentric lymphoma, and it spreads rapidly. Lymphoma is typically found in middle-aged or senior dogs, and certain dog breeds are more prone to developing this cancer, possibly due to a genetic component.
Some dog breeds that have a higher risk of developing lymphoma include:
- Golden Retrievers
- Basset Hounds
- Scottish Terriers
- Saint Bernards
- Airedale Terriers
When it comes to lymphoma, there are typically four different types:
- Multicentric (systemic) lymphoma. The most common type of lymphoma in canines. Multicentric lymphoma accounts for around 80% of lymphoma cases in dogs. Lymph nodes throughout the body are affected by this type of cancer.
- Alimentary lymphoma. This type of lymphoma occurs in the gastrointestinal tract. This is coming in as a close second when it comes to common types of canine lymphoma.
- Mediastinal lymphoma. This form of lymphoma is rarer and affects the lymphoid organs found in the chest, such as the lymph nodes or the thymus.
- Extranodal lymphoma. This type of lymphoma is also very rare, but it does happen. It targets a specific organ that is not a part of the lymphatic system. It develops in areas like the skin, eyes, kidneys, lungs, or nervous system.
Like human cancers, canine lymphoma is broken into different stages to signify the degree to which it has spread throughout the body.
Canine lymphoma stages are as follows:
- Stage I – cancer is contained to one single lymph node in the dog’s body
- Stage II – cancer is contained to multiple lymph nodes on one side (either the top side or the bottom side of the dog)
- Stage III – cancer is only contained in the lymph nodes themselves but is found in various nodes in the dog’s body
- Stage IV – cancer is located in the dog’s spleen and liver, regardless of whether it started there or spread there
- Stage V – cancer is located in various parts of the body, or the bone marrow or central nervous system
Symptoms of Lymphoma in Dogs
Unfortunately, we don’t know exactly why lymphoma develops in our furry friends. There have been theories about viruses, bacteria, chemical exposure, and physical factors being possible reasons. Suppression of the immune system is a risk when it comes to lymphoma in humans, but the link between suppressed immunity and lymphoma in dogs has not yet been established. More research will have to be conducted for us to fully understand.
The most common and the first physical symptoms of canine lymphoma are firm, enlarged, swollen, non-painful lymph nodes. Lymph nodes affected by lymphoma often feel hard or rubbery beneath your dog’s skin. It’s easiest to locate the nodes near the neck or the mandibular lymph nodes. These are right under the jaw. Or you can locate the popliteal lymph nodes, the ones that reside behind the knee.
More symptoms include lethargy, weight loss, loss of appetite, swelling of the legs or face (also called edema), and sometimes even increased urination or thirst. If you notice your dog’s lymph nodes feel firm and rubbery and your dog has been displaying one or more of these symptoms, you may want to make an appointment with your vet to rule out lymphoma.
Symptoms of Cutaneous Lymphoma
One of the first signs of cutaneous lymphoma is dry, flaky, red, and itchy patches of skin located anywhere on the dog’s body. The skin will become moist, irritated, ulcerated, bright red, and thickened as the disease progresses. It can also be found in the mouth, affecting the lips, gums, and roof of the mouth.
Masses in the skin also occur in cutaneous lymphoma. This type of cancer has many times been treated as an allergy or infection before the diagnosis was made. If you find that your dog’s lymph nodes are hard and swollen, and your vet suggests it may be allergies or an infection, please keep this in mind. Cutaneous lymphoma of the mouth is also often mistaken for periodontal disease or gingivitis in the early stages. It may be worth getting a second opinion.
Symptoms of Alimentary Lymphoma
Dogs suffering from gastrointestinal lymphoma will often exhibit symptoms such as vomiting, frequent watery or loose stools, lethargy, and noticeable weight loss. Diarrhea will typically be darker in color and foul-smelling. Males have a higher predilection as opposed to females.
Symptoms of Mediastinal Lymphoma
Canines with mediastinal lymphoma usually have difficulty breathing due to a large mass within the chest and/or the accumulation of fluid inside the chest cavity. You may also notice your dog’s front legs or face is swollen or puffy-looking.
If you believe your dog may have some type of lymphoma, take them to a licensed veterinarian as soon as possible to be checked out. It’s important to realize that not all swollen lymph nodes immediately mean cancer. Similar to humans, infections can cause swollen lymph nodes. However, since canine lymphoma is serious, you’ll want to be safe and have it checked out.
While rubbery or hard lymph nodes are the biggest player in canine lymphoma, that doesn’t mean it will always be easy to see or feel them on your dog. Sometimes they will be in places that make it difficult to notice. If you don’t know if your dog has swollen lymph nodes, but they display some of the other warning signs we mentioned, take them to the vet anyways for a routine checkup.
CBD Oil for Lymphoma in Dogs: Can It Help?
Cannabidiol is pretty successful at managing and controlling symptoms of the disease and the negative side effects of the chemo. CBD has also been used as a health supplement for dogs even if they are not fighting diseases or cancer, as it promotes overall wellbeing in pets.
If your dog is having chemotherapy treatments, administering CBD oil to your dog’s tongue regularly may be able to promote a bit of an appetite and give them a mild boost in energy. This will help them maintain their energy levels while undergoing treatment.
CBD is a hemp-derived product; however, it is not intoxicating like THC. It will not get your dog high whatsoever; the most it will do is calm your dog down a little bit and make them feel a bit better if they are in pain.
CBD oil has been regarded as a natural pain reliever, so CBD oil may be a safe choice for helping them through the pain they experience either from the disease itself or the treatment plan. Forms of lymphoma that create a bit more inflammation in your dog’s body may be able to be managed by CBD due to its powerful and natural anti-inflammatory benefits.
Another positive about using CBD for dogs undergoing treatment for lymphoma is that the cannabidiol will effectively be able to calm them down and relax them, preventing them from getting wound up or anxious when they have to visit the vet.
Keep in mind that while CBD has been known to help control the unwanted side effects of canine lymphoma, it is not a treatment, cure, or prevention for this disease.
Using and Choosing a CBD Oil for Dogs
Administering CBD oil to your dog is relatively simple. You can usually find it in tincture form, treat form, or capsule form when it comes to canine products. Tinctures don’t always go over well with picky pups and capsules may be hard to hide away in a chunk of cheese. However, CBD-infused treats seem to be more tolerable to dogs, as the flavor is masked by other ingredients.
You can also create your own CBD dog treat by simply finding a porous treat that your dog loves, and letting the dose soak into the surface for a minute before giving it to your four-legged friend. So know that you know how to give your dog CBD, you’ll want to know how to choose the right product.
Pets are part of the family, so you are going to want to follow the same rules you’d follow if you were shopping for a CBD product for yourself.
Choosing the Form
Like we mentioned before, you’ll probably be choosing between tinctures, capsules, or CBD-infused treats. Tinctures are typically the best value, as in you get the most product for your money, it will last longer, you can easily choose and change doses, and it is the fastest-acting method.
If it stresses your dog out to try to get them to open up and take the dropper-full, capsules or treats should be considered as an option.
Quality, Ingredients, and Safety
Ingredients are important. Wouldn’t you want to know what exactly is in a product you are ingesting every day? Well, it’s up to you to do that for your dog because he can’t. Make sure the ingredients are safe and organic, the company is legit and trusted, and the products are lab tested.
Most products will state that they are “all-natural” because it appeals to consumers, but are they? This is why it is important to pay attention to the ingredient list and lab results.
Full-spectrum vs. Isolate
It’s also good to note the differences between full-spectrum CBD and CBD isolate. Cannabidiol in full-spectrum form is made from the entire hemp plant, containing nutrients, terpenes, and other cannabinoids, which all work together to maximize the user’s benefits.
CBD isolate may not work as effectively on its own, but it is a pure product. If you want CBD and nothing else, you’re going to want to go with a CBD isolate. Remember the difference when shopping for a CBD product for your dog.
CBD vs Traditional Treatments for Canine Lymphoma
Unfortunately, canine lymphoma is not curable. It can go into remission, similar to cancer in humans. Canine lymphoma often returns, and the treatments may be able to give your dog around an additional three years of life.
Chemotherapy is the normal option, sometimes with radiation and surgery used in conjunction with other forms of managing cancer. However, surgery is not the first choice due to the disease not wanting to stay in one spot. The goal behind canine lymphoma treatment is to help cancer go into remission and manage the dogs’ symptoms so that they can have a better quality of life. If cancer goes into remission, signs and symptoms are typically gone unless it returns.
Treatment should be executed soon after diagnosis. Some owners will put off chemotherapy because their dogs don’t seem “too sick” yet, and they fear the treatments will make them sick. However, treatment is much more successful when it is started when the dog is in the early stages, and his or her health has not begun diminishing yet. Remission may not be possible if you wait to start the treatment and allow your dog to progress further on into the disease.
Side Effects of Chemotherapy in Dogs
The side effects on dogs are not as brutal as they are on humans, however, your dog may or may not experience some side effects from the chemotherapy. Some of the side effects that may experience include:
- Neuropathic pain following the treatment
- Lethargy or fatigue for the days following the treatment
- Whisker loss
- Decreased appetite
- Thinning fur and fur loss (rare)
- Extreme tiredness, not wanting to get up or move
While there isn’t a treatment or cure for canine lymphoma, there are ways to potentially lessen the severity of your dogs’ symptoms to allow them to live a more comfortable, happy life while they are still with you. That is where CBD comes in. This may also be an option if your dog reacts poorly to the chemotherapy treatments, as your vet may be open to experimenting with this natural alternative.
Suppose your dog is facing any type of lymphoma and they are undergoing chemotherapy as a treatment. In that case, CBD may be able to help your dog feel a bit more comfortable and content during this difficult time.
While CBD comes from the hemp plant, it is non-psychoactive and will not get your dog intoxicated. Cannabidiol may be able to increase appetite, reduce physical pain, reduce inflammation in the body, and calm your dog down before their vet visits.
- Saba Omer, Dawn Boothe, Mohammedohammed Mansour, Muralikrishnan Dhanasekaran and Satyanarayana Pondugula, November 1, 2020 (1) (3 Supplement) PO-28 (1)
- Jeremy R. Johnson, Mary Burnell-Nugent, Dominique Lossignol, Elena Doina Ganae-Motan, Richard Potts, Marie T. Fallon, 2010, Pages 167-179 (2)
- Osvaldo Marinotti & Miles Sarill (2020) 17:5, 517-526 (3)
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
Compare the Best CBD for Lymphoma in Dogs for 2022
Spruce’s dog-friendly CBD has been specially formulated for dogs. Instead of hemp seed oil for the carrier oil, the product contains coconut oil, which is generally easier on the digestion for dogs. The taste is also milder with no flavorings, making it more likely that dogs will eat it with their food.
Using Spruce CBD for dogs is simple. All owners have to do is sprinkle the desired dose on the dog’s food at mealtime once or twice a day. Each dose should consist of about two to three drops per 20 pounds of dog weight.
2. Honest Paws Wellness Oil for Dogs
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Product offering is extensive
Most products were not tested for solvents or mycotoxins
Products are made from 100% organic, non-GMO, and locally grown hemp
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A calming full-spectrum hemp oil that combines naturally occurring CBD with other ingredients for healthy immunity, calm moods, and a healthy brain.
3. Nuleaf Naturals Pet CBD Oil
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No other flavors
CBD for dogs, cats and other four-legged friends! Our product is concentrated to approximately 50mg cannabinoids per milliliter of oil. While this product is designed for pets, it’s great for humans, too.
4. 4 Corners Cannabis Pet Tincture
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Has a wide variety of CBD strengths
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4 Corners Cannabis Pet Tinctures are generous on their options since there are different sizes and strengths available for you exact needs. The flavor peanut butter is available perfect for pets who are picky when it comes to eating.
5. cbdMD Pet CBD Oil Tincture for Dogs
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Same CBD Oil benefits as for humans
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With nothing but MCT oil combined with CBD oil sourced from U.S. hemp that is grown using organic farming methods, these CBD Oil Tinctures for Dogs can be added to their favorite foods while still providing the same effects that you enjoy. We have two flavors to choose from: Natural and Peanut Butter.
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How CBD Helps With Lymphoma in Dogs
Cannabidiol (CBD) is a non-psychoactive drug extracted from the cannabis plant. CBD possesses anti-cancer properties (1) . These benefits may help manage lymphoma in dogs .
A review published in 2016 mentioned that cannabinoids may potentially prevent the growth and spread of cancer cells and stimulate the immune system ’s response against the disease (2) .
CBD is a cannabinoid that comes from the Cannabis sativa plant.
Some trials in the review were conducted on mice. However, one study suggested that CBD may work similarly in other animals, except insects, because the animals’ endocannabinoid system (ECS) functions similarly across all species (3) .
The ECS is located in the animal’s central nervous syste m and is responsible for regulating the body’s balance and maintaining the dog’s quality of life (4) .
The interaction of CBD with the ECS receptors in the nervous and immune systems may have various benefits . These benefits include anti-anxiety effects, anti-inflammatory properties, and potential anti-cancer effects on canines (5) .
There are different types of cancer among dogs, and lymphoma is the most common. Scientists have little understanding of what causes canine lymphoma . However, dogs are exposed to similar environmental factors that cause cancer among humans (6) .
Lymphoma is an umbrella term for any type of cancer that emerges from lymphocytes .
Lymphocytes refer to a group of white blood cells that help fight infection. Lymphocytes are located in the lymphatic system composed of the lymph nodes , bone marrow , and spleen.
Veterinarians diagnose canine cancer by taking a sample of the dog’s lymph nodes or affected organ.
Some vets may also perform staging tests to determine how much the disease has progressed. These tests include blood tests, X -rays, urinalysis, bone marrow aspiration, and abdominal sonograms.
The aggressiveness, survival rates , and symptoms of lymphoma may vary depending on the type of lymphoma . For canine lymphoma , the four most common types are (7) :
- Multicentric lymphoma – This type of lymphoma is the most common among dogs and is characterized by the rapid enlargement of lymph nodes.
The swelling lymph nodes may grow 3 to 10 times the average size. However, they are not painful and only feel like a firm, rubbery lump under the skin.
As multicentric lymphoma progresses, dogs may show other symptoms, including fever, weakness, lethargy, anorexia, and dehydration.
- Alimentary lymphoma – This form of canine cancer is the second most common and usually targets the dog’s intestinal organ.
Dogs with alimentary lymphoma may experience vomiting, diarrhea, anorexia, abdominal pain, and weight loss.
- Extranodal lymphoma – This form of lymphoma affects a specific organ like the eyes, skin, kidneys, or lungs.
Cutaneous lymphoma targets the skin and is one of the common forms of extranodal lymphoma.
Symptoms vary on the area where extranodal lymphoma occurs. For example, cutaneous lymphoma appears as raised nodules or scaly lesions on the skin, lips, or the roof of the mouth.
Extranodal lymphoma occurring in the central nervous system may cause seizures.
Meanwhile, extranodal lymphoma in the bones differs from primary bone cancer because lymphoma does not start in the actual bone cells. Lymphoma in the bones may also cause fractures or pain.
- Mediastinal lymphoma – This type of cancer in dogs is one of the rare forms of lymphoma. Mediastinal lymphoma affects the mediastinal lymph nodes and the thymus located between the lungs.
Dogs with mediastinal lymphoma may have difficulty breathing because of the tumor growth or fluid accumulation within the chest. Other signs include swelling of the front legs or face, extreme thirst, or urination.
Currently, the most effective cancer treatment for dogs is chemotherapy (8) . The veterinarian’s chemotherapy recommendation may vary depending on the diagnosis or type of lymphoma .
For example, dogs with multicentric lymphoma may be given the UW-25 chemotherapy protocol.
This protocol is a 25-week chemotherapy session using four chemotherapy drugs known as CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine sulfate (Oncovin), and prednisone).
Typical side effects of chemotherapy in dogs are diarrhea, mild vomiting, reduced appetite, and decreased activity levels (9) .
Benefits and Use of CBD for Lymphoma in Dogs
A study published in The Young Researcher in 2018 mentioned that CBD may be effective in inducing apoptosis (cell death) in many types of cancers , including diffuse large B-cell lymphoma (DLBCL) (10) .
The in vitro study indicated that CBD may have a strong potential to help reduce DLBCL and minimize cancer relapse. However, additional studies in vivo are needed to determine if the results are similar for dogs with lymphoma .
DLBCL is known to be the most common aggressive B-cell lymphoma affecting dogs worldwide (11) .
CBD i s known for its anti-inflammatory properties (12) . These effects may help manage multicentric, extranodal, and mediastinal lymphoma by reducing symptoms such as swelling and inflammation.
CBD also provides analgesic (anti-pain) effects (13) . Such properties may help alleviate pain associated with alimentary or extranodal lymphoma .
CBD Oil Dosage for Dogs With Lymphoma
Currently, there is no Food and Drug Administration-approved dosage guide for CBD products for the management or treatment of canine lymphoma .
However, a 2019 study performed on healthy dogs and cats stated that 2 milligrams of CBD per kilogram of body weight may be a viable dosage with no harmful side effects (14) .
A study in the American Journal of Veterinary Research examined the efficacy of repeated oral administration of CBD among healthy adult beagles (15) .
The study mentioned that doses of 1 to 12mg/kg of CBD administered once daily over 28 days are well tolerated among dogs.
Caution is advised when attempting to administer high doses of CBD in dogs. Higher CBD dosage side effects include dry mouth, drowsiness, or low blood pressure (16) .
You may start with lower doses of CBD for your dog, especially when you are still starting to use CBD for your pet.
Various factors like the dog’s size and weight may influence the CBD dose amount.
Tetrahydrocannabinol ( THC ), another cannabinoid present in some CBD products , has potentially toxic effects on canines at specific doses (17) .
Inform your veterinarian about your dog’s condition before deciding if CBD is suitable for your pet.
However, most states have laws prohibiting veterinarians from prescribing or administering cannabis -based products (18) .
How to Administer CBD for Dog Lymphoma
There are various ways for pet owners to administer CBD products to dogs with lymphoma . Here are some ways dogs may take CBD.
- CBD oil tinctures are administered sublingually or under the tongue. These tinctures usually come with a dropper or spray for easy administration of CBD to your dogs.
Sublingual administration enables the CBD oil to enter the bloodstream faster, allowing for faster absorption.
CBD tinctures are often mixed with carriers such as hemp seed oil or coconut oil to dilute the CBD.
- CBD capsules are administered orally, allowing the CBD to pass through the digestive tract before being absorbed by the body.
Another alternative to administer CBD capsules to your dog is to sprinkle the capsule’s contents onto the dog food .
- CBD edibles such as soft chews, biscuits, or dog treats are also administered orally. These products come in different servings, flavors, and doses.
- CBD topicals are applied to the dog’s skin. Some topicals for dogs include creams, massage oils, and balms.
How Long Does CBD Take to Help Lymphoma in Dogs ?
Onset times of CBD oil on dogs may vary based on the dosage and route administration.
Sublingual administration using an oromucosal spray or dropper allows CBD to directly enter the bloodstream under the tongue and bypass the digestive tract, leading to faster onset times.
Oral administration by ingesting edibles or capsules allows CBD to pass through the dog’s digestive tract then break down in the liver. This administration method has a slower onset time.
CBD applied topically, such as creams or lotions, may start to take effect depending on the skin thickness. Topicals usually work for skin problems or joint pains and do not get absorbed into the bloodstream.
One study stated that the thickness of the dog’s skin or absorptivity of the CBD-infused topicals may limit transdermal absorption (19) .
Transdermal delivery involves applying CBD topical through the skin so that it is slowly absorbed by the body.
Aside from dosage and administration methods, onset times of CBD products may also vary depending on the dog’s size and weight.
How Long Will CBD Help With Lymphoma in Dogs ?
A 2018 animal study showed that the elimination half-life of a 75mg dose of CBD-infused oil is 199.7 ± 55.9 minutes, while a 75mg dose of CBD micro-encapsulated capsule was at 95.4 ± 29.2 minutes (20) .
Half-life is the duration for the drug’s quantity to be decreased to 50%.
In the same study, the researchers could not ascertain the elimination half-life of 75mg of CBD transdermal creams. This result was due to the lack of an elimination phase in the concentration -time profiles.
Thus, the researchers suggest that additional trials with a more extended period of CBD administration for at least several months be conducted.
Extending the trial duration may provide a better assessment of CBD concentrations and time of effectiveness.
Side Effects and Risks of Using CBD for Lymphoma in Dogs
Some dogs taking CBD may experience diarrhea, vomiting, loss of appetite , or lethargy. Ataxia may also affect the dog’s coordination and balance, especially when CBD is ingested in large doses (21) .
Other side effects of CBD in dogs include dry mouth, drowsiness, and low blood pressure (22) . While these effects may be well tolerated among humans, the pets’ tolerance to these side effects may vary.
One study regarding the safety of increasing CBD doses conducted on beagles mentioned that dogs may tolerate CBD dose volumes of up to 640.5mg or around 64.7mg of CBD per kilogram of the dog’s body weight (23) .
The study also stated that CBD oil formulations with higher CBD content are safer and well tolerated than those with higher THC content.
CBD may inhibit the cytochrome P450 enzyme in the body. If your dog is taking other medication, CBD’s effect may limit or interfere with the drug’s metabolization.
Consider seeking advice from your veterinarian regarding your dog’s condition and medication before purchasing CBD products for your pet.
How to Shop for the Best CBD Oil for Dogs With Cancer
Dog owners should consider the following factors when looking for high-quality CBD products that may work best for their pets:
- Extraction method – CBD is extracted from the cannabis plant using CO 2 , ethanol, or hydrocarbon extraction.
CO 2 extraction uses liquefied CO 2 to extract CBD and other components. This method does not use combustible solvents and poses no threat of catching fire (24) .
Ethanol extraction uses ethanol to pull the CBD oil from the hemp plant .
Hydrocarbon extraction uses hydrocarbon solvents like propane or butane for CBD extraction. Hydrocarbons are flammable and may be harmful to the dog’s health if not properly removed from the extracted CBD oil.
- Cannabinoidcontent – Full-spectrum CBD oil contains all the naturally occurring cannabinoids and compounds in the cannabis plant.
These compounds include THC , terpenes , flavonoids, and fatty acids . Combining these compounds produces an entourage effect that enhances the benefits of CBD oil than when the compounds are taken individually (25) .
However, THC may cause intoxication on canines resulting in stumbling, vomiting, lethargy, agitation, or shaking (26) . Consider broad-spectrum products or isolates as alternatives for your pet.
Broad-spectrum CBD oil has the same cannabinoid content as full-spectrum without the THC .
CBD isolates contain only pure CBD without the other cannabinoids and compounds present.
- Certificate of analysis (COA) – B rands selling CBD products must have updated COAs accessible on their websites.
The COA shows the CBD product ’s actual cannabinoid content and the presence of pesticides and contaminants, if any.
Credible CBD products must have the details on their labels matched with the COA results.
- CBD producttype – Dog owners may choose from various CBD products depending on their preferred dosage or route of administration.
CBD oil tinctures are administered sublingually or under the tongue. Edibles like dog treats or chews are taken orally. Capsules are also administered orally. CBD topicals like creams or lotions are applied to the skin.
Legality of CBD
To date, the FDA has not provided approval for cannabis use on dogs. The agency is unable to guarantee the safety and efficacy of these products on animals (27) .
Review your local and state laws regarding the legal consumption of CBD for your dogs before purchasing pet CBD products .
Most states have legislation prohibiting veterinarians from prescribing or administering CBD for dogs (28) .
However, Nevada-based veterinarians may recommend and administer CBD products that contain less than 0.3% THC (29) .
How can CBD help with lymphoma in dogs?
CBD has anti-inflammatory properties (30) . These benefits may help manage the symptoms of multicentric, extranodal, and mediastinal lymphoma .
CBD also has pain relief effects (31) . Such properties may help reduce pain associated with alimentary and extranodal lymphoma .
What evidence or research exists to say that CBD helps with lymphoma in dogs?
CBD’s anti-cancer properties may help reduce diffuse large B-cell lymphoma (DLBCL) and minimize cancer relapse (32) . However, additional studies must be performed to determine if CBD may help dogs with lymphoma .
DLBCL is known to be the most common aggressive B-cell lymphoma affecting dogs worldwide (33) .
Is there any evidence that CBD can make lymphoma in dogs worse?
To date, there is no evidence of CBD causing canine lymphoma to worsen. However, CBD may have side effects on dogs, such as dry mouth, drowsiness, or low blood pressure (34) .
CBD products containing high levels of THC may be toxic for dogs (35) . Talk to a veterinarian about your dog’s condition and research the THC levels on CBD products before purchasing one for your pet.
Will CBD interact with any current medication taken for lymphoma in dogs?
CBD may interact with other medications by inhibiting the cytochrome P450 enzyme in your dog’s body . This effect may interfere with the metabolization of drugs.
Ask your veterinarian about your dog’s condition and medication before purchasing CBD products for your pet.
Are there other treatments I should consider alongside CBD to help with lymphoma in dogs?
Currently, the most effective cancer treatment option for lymphoma in dogs is chemotherapy (36) . The type of chemo usually depends on the vet’s diagnosis and cancer type.
What is the dosage for lymphoma in dogs?
Currently, there are no FDA-approved doses for CBD products for managing or treating canine lymphoma .
One study mentioned that 2 milligrams per kilogram (mg/kg) of CBD may be a viable dosage for dogs with no harmful side effects (37) .
Do veterinarians recommend CBD for dogs with lymphoma?
Most states have laws prohibiting veterinarians from recommending, prescribing, or administering cannabis -based products for dogs (38) .
In Nevada, veterinarians may recommend and administer CBD products that contain less than 0.3% THC (39) .