CBD appears to work in a more indirect manner. It does not appear to have much of an affinity for binding directly to cannabinoid receptors. Rather, it appears to influence things like receptor-independent pathways and ion channels. In fact, a study from 2019 discusses how treatment with “low-dose CBD” can induce pain-relieving effects in rats via TRPV1 (a non-selective cation channel) activation.
There is, however, data that supports the use of CBD for helping with various forms of pain. Fibromyalgia is of course a very painful condition, so is there a possibility that CBD oil could help? Keep reading to discover relevant information about CBD oil, fibromyalgia, chronic pain, and more.
Studies on Cannabinoids (i.e. CBD Oil) for Fibromyalgia
Chronic pain is one of the most common reasons people take CBD oil. Fibromyalgia sufferers are beginning to take notice of its potential benefits.
As such, those inquiring about the use of CBD for fibromyalgia may be interested in learning more about the general pain-relieving potential of CBD. The National Institute of Health’s (NIH) PubChem database identifies the structure and molecular form of CBD, and defines it as a cannabis compound with “analgesic, anti-inflammatory, antineoplastic and chemopreventive activities.”
Everyone is different, and it is important to remember that CBD products do not produce a psychoactive effect (as do THC products). There’s a chance users may not feel anything in terms of therapeutic relief, but there should be no chance of experiencing anything mind-altering or psychoactive. Many users take CBD oil in the hopes of feeling less pain. Others take it with the aim of achieving an overall sense of calm and relaxation. nd maybe even whole-body relief. Depending on the person, CBD oil can vary in terms of how long it takes to take effect. It may take a while to experiment with different milligram amounts, but this effort is well worth it in the long run.
You’ve long been able to find a lot of claims by hemp growers and CBD sellers that their product is legal in all 50 states as long as it contains less than 0.3 percent THC. However, a 9th Circuit Court of Appeals ruling disagreed.
The website ProCon.org has information about which states have laws specific to CBD oil. A site called Governing maintains a map of where marijuana is legal in some form.
As of mid-2018, CBD oil is not FDA-approved for any conditions. Research in the United States is in the early stages, though, since for decades, legal restrictions made it extremely difficult to study the medical benefits of marijuana or any of its components. We may see applications submitted to the agency as research continues to move forward.
Is CBD Oil Legal?
You’d think the question, “Is CBD legal?” would be answerable with a simple yes or no. It hasn’t been, and while it’s getting easier to answer that question, it’s still not cut-and-dried (nor is the question of whether or not CBD oil can result in a positive drug test).
People are using CBD oil for a lot of different medical purposes, including:
First, we have a pain epidemic in the U.S., and fibromyalgia is a major contributor to that. Current treatments just aren’t good enough for most of us, so there’s an enormous financial incentive to find something that’s better at relieving our pain and other symptoms.
We don’t have a full picture of the possible side effects of CBD. Some reported side effects include:
Dr. Ginevra Liptan, director of The Frida Center for Fibromyalgia and author of “The FibroManual: A Complete Fibromyalgia Treatment Guide For You. And Your Doctor,” reported that many of her patients have experienced relief from symptoms such as muscle tension, pain, anxiety, and insomnia as a result of combining CBD oil with their mainstream medications. Like Habib, however, she emphasizes that CBD oil appears to be more effective when teamed with THC.
She, therefore, endorses the use of full-spectrum CBD oils for fibromyalgia. “I see much greater benefit from full-spectrum CBD oils, which contain other cannabinoids and sometimes trace amounts of THC, compared to the CBD isolates, which do not have the synergistic effects of the whole plant extract.”
There is still no research specifically investigating CBD oil as a treatment for fibromyalgia. However, in 2018 research was published in the “Journal of Clinical Rheumatology” suggesting medicinal cannabis may represent an effective treatment for the illness.
What the experts say
Habib does point out that the patients in the study consumed oil containing both CBD and THC extracts. “A small fraction of our patients used oil, and mostly containing THC, so only a very small number of patients used pure CBD oil,” he said.
CBD may alleviate certain symptoms associated with fibromyalgia, such as pain, sleep disruptions, anxiety, and depression. Photo by: Gina Coleman/Weedmaps
The brain is one of the key areas affected by fibromyalgia, with brain inflammation contributing to pain and brain fog. Recent research suggests that microglia in the brain and spinal cord play a role in fibromyalgia. When certain cells become activated, they can contribute to inflammation by amplifying pain signaling and transmission.
Dr. George Habib is the co-author of a 2018 retrospective review study in the “Journal of Clinical Rheumatology” investigating medical cannabis as a treatment for fibromyalgia, and he believes it offers fibromyalgia patients hope. ”In general, the impression (from the study) was that this type of medication is more effective than pregabalin and duloxetine,” Habib said.