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cbd oil for mitochondrial disease

Mitochondria are primarily responsible for creating energy for the cell and for the body.

There are "acid" and "neutral" forms of every cannabinoid molecule. Early man knew the difference and would either just eat the cannabis raw, or heat it to convert to the neutral or "active" forms of the cannabinoids.

Over the past several years we have been using more and more THC-Acid (THC-A.) Many of you may be familiar with the differences between THC and THC-A.

What I Discovered

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The effectiveness of current treatments for mitochondrial disease varies from patient to patient and depends on the type of affected cells and the severity of their disease. In general, those with milder mitochondrial disorders will experience more success with treatment than those with severe mitochondrial disorders. Some patients can experience symptom relief and slowed progression of mitochondrial disease with treatment programs tailored expertly to their specific set of symptoms. For other patients, however, personal treatment plans that should be effective do not result in benefits or improvement.

Medical cannabis for mitochondrial disease offers excellent potential as a treatment because of the antioxidant properties of some cannabinoids and the ability of cannabinoids to regulate mitochondrial activity. Cannabinoids can help balance oxidative stress that is a natural byproduct of mitochondrial function. When mitochondria convert nutrients to energy, it necessarily produces some oxidative stress. If oxidative stress is too high, the body may release damaging free radicals that interact with cell membranes, proteins, DNA and other organelles. Antioxidants protect against damage from oxidative stress by neutralizing free radicals. Because the cannabinoids THC and CBD both have antioxidant properties, medicinal weed may help to reduce the damage from oxidative stress caused by dysfunctional mitochondria.

Because mitochondrial diseases can vary so widely, patients should consult a physician before beginning any treatments, including altering their diet.

Current Treatments for Mitochondrial Disease

Medical marijuana for mitochondrial disease may help maintain the balance of autophagy and apoptosis in cells in varied ways. THC in smaller doses can increase mitochondrial activity by interacting with the mitochondrial membrane to promote the creation of ATP. This process also aids in cell regeneration by triggering autophagy that repairs damaged cell parts. Higher doses of THC can decrease the activity of mitochondria by binding to CB1 receptors to decrease mitochondrial activity and thus decrease oxidative stress. Cannabinoids may also suppress neurodegeneration to slow the aging process and slow the onset of dementia.

Because the effects and symptoms of mitochondrial disease vary so much between patients, there is not a one-size-fits-all medical marijuana treatment. Some patients may find success with high-CBD strains of marijuana, such as Harlequin and Sweet and Sour Widow. Other patients may find more relief in heavy-THC strains, such as Blackberry Kush and White Russian. Individual patients can also ingest medical marijuana in a variety of methods to suit their needs. For example, those who experience respiratory problems associated with mitochondrial disease may choose edibles or topical treatments, while a patient with muscle pain or loss of motor control may want to smoke or vaporize their medicinal weed. Finding the right strain and treatment method for mitochondrial disease may require some trial and error until a patient discovers the best treatment for them.

A variety of clinical studies have been performed to examine the effects of cannabinoids on mitochondrial activity. Research suggests that cannabinoids interact with mitochondria in a way that improves and regulates their function. These studies provide support for medical marijuana as a valid treatment option for mitochondrial diseases.

The success of treatment for mitochondrial disease also happens on a case-by-case basis. Some patients will see immediate benefits from therapy, while others may not experience benefits until several months into treatment programs. For others, treatment for mitochondrial disease may effectively slow the progression of the disease on a cellular level without displaying any noticeable relief of symptoms for the patient.