CBD is a naturally occurring chemical compound that is situated within the cannabis plant. It is one of over a hundred other cannabinoid compounds that are present in the plant, and it’s the second most commonly occurring, topped only by the high-inducing cannabinoid, Tetrahydrocannabinol (THC). Unlike THC, however, CBD is non-intoxicating, and you can safely go about your daily tasks after consuming. Because of the compound’s antioxidant, anti-inflammatory, and neuroprotective properties, CBD boasts a broad spectrum of potential therapeutic benefits. It also modulates higher numbers of the brain’s biological targets (such as receptors, channels) involved in the development and maintenance of neurodegenerative diseases.
To understand the causes and characteristics of neurological conditions, you first need to understand a little bit about the nervous system.
Sativex is a mouth spray containing two chemical extracts delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). In the UK, the medication is approved for the treatment of spasticity in multiple sclerosis, though it is not allowed to treat pain in the same condition. Sativex is a Class B controlled drug under the Misuse of Drugs Act 1971 and is placed in less-restrictive Schedule 4 according to the Misuse of Drug Regulations 2001. Sativex can be prescribed by a specialist doctor experienced in the treatment of multiple sclerosis, such as consultant neurologists, consultant rehabilitation specialists, and consultant pain specialists. The drug can be prescribed legally in the UK with no restrictions on storage, supply and destruction.
Migraines are much more than intense headaches. They include a number of neurological symptoms, such as a throbbing recurring pain on one side of the head and muscle stiffness. Fortunately, a 2019 review suggested that cannabinoids may be able to modulate the activity and functions of signalling pathways, helping to alleviate the pain associated with migraines. Initial clinical findings show that modulation of the endocannabinoid system with cannabinoids may be helpful for migraine. Whatsmore, a 2007 study also suggested that people with migraine might have low anandamide levels in the cerebrospinal fluid, which signifies that they may have a compromised ECS. Therefore, modulation of the ECS with cannabinoids could become a promising treatment for migraines. Nevertheless, further studies are required to take place before we fully understand this process.
Produced by GW Pharmaceuticals, Epidolex is a plant-derived cannabidiol-based medicine that is predominantly used to treat seizures associated with Lennox-Gastaut syndrome and Dravet syndrome in children. NICE, the UK’s drugs advisory body, followed the recommendations of the European Commission, who suggested that the combination of Epidiolex and anti-epileptic generic drug clobazam (brand names Onfi and Sympazan) for the patients, aged two and older. As of 2019, out of the 3,000 people who had Dravet syndrome and the 5,000 people who suffered from Lennox Gastaut syndrome, 2,000 people could qualify for Epidiolex in England.
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But, until then, the little research studies that have been done so far stood in favor of the therapeutic effects of CBD Oil. It has provided relief to mostly all of the patients who used it. We have reviewed the best CBD Oil for Neurological Disorder available in the market.
Neurological disorders are diseases in which the peripheral and central nervous system doesn’t function properly. Or we can just say that the system of the spinal cord, brain, peripheral nerves, cranial nerves, autonomic nervous system, and muscles stops working.
When these disorders take place they cause Parkinson’s disease, epilepsy, dementia, cerebrovascular diseases, brain tumor, neurological disorders, and many others. Millions of people get affected by neurological disorders worldwide.
In middle-income countries, More than 6 million die a horrible death because of a stroke every year. 50 million people are suffering from epilepsy nowadays. In the same way, the percentages of other neurological disorders are also increasing and mainly in low-income countries.
The oil is full-spectrum which means it extracts the best of the hemp plant. The oil is lab tested. It is also third party tested and is highly recommended. It does not contain any unnatural process of synthesis.
Have you ever thought that what if your nervous system stops working? What would you take as a medical intervention technique? Would it be satisfactory? No one can tell for sure that whether a specific drug or surgery will cure the nervous disorders but what if there is a way around which doesn’t have any side effects. And, you haven’t even tested it yet.
We believe that when nutritional supplements are recommended for either a specific disease (e.g., Parkinson disease) or general health benefits (e.g., cognitive function), there should be valid data to support those claims—data that are independent of bias created by placebo responses, financial gains, or other factors. Government should help to protect people from harm—whether the harm comes from spending money on products that do not deliver on their promise or have the potential to cause adverse effects that do not outweigh their harmful effects. Our governments make it illegal to sell a television that does not work but have allowed the dietary supplement industry to make innumerable health claims, which have no evidential basis and, in many cases, have been even refuted by scientific data. We therefore applaud the efforts of governmental agencies to identify fraudulent claims about compounds purported to contain CBD in which CBD is wholly absent or present in miniscule amounts.
The challenge now for scientific medicine is that the “horse is out of the barn”. A wave of cannabis legislation, driven in part by medical claims and also by a changing societal view of recreational cannabis use, has washed across the USA, Uruguay, and Portugal, and will likely spread elsewhere as pressure from patients, their parents, and advocates demand access for its use in a range of disorders that can impair or destroy quality of life, or kill. Randomized placebo-controlled studies have been the main road to governmental approval of drugs and devices for the last half century and remain the gold standard by which efficacy is objectively judged. Yet cannabis has effectively bypassed that road by virtue of a ‘perfect storm’ made up of medical lack of interest, commercial unpalatability, societal acceptance of the naturalistic fallacy, and urgent unmet clinical need. A diverse range of cannabis plant strains, rich in different proportions of the 100 or so phytocannabinoids that have been identified, have been bred, and complex and often hazardous processing techniques devised to increase and extract specific components such as CBD or THC-acid, with highly variable results. These products are being used by consumers—from children with severe epilepsy to patients with chronic pain or insomnia or anxiety or cancer. There is a growing group of lay experts who profess knowledge of the correct mixture of constituents (e.g., “You need at least 2 % THC with the CBD to stop seizures”, or “CBD will not work if the child is taking leviteracetam”) who lack data and, often via association with alternative medicine schools of thought, do not feel beholden to the medical establishment’s basic demand for objective proof of safety and efficacy. We are moving back to days of Paracelsus and alchemy but multiplied by the echo chamber of social media and growing scientific illiteracy .
The force of the recent explosion of largely unproven and unregulated cannabis-based preparations on medical therapeutics may have its greatest impact in the field of neurology. Paradoxically, for 10 millennia this plant has been an integral part of human cultivation, where it was used for its fibers long before its pharmacological properties. With regard to the latter, cannabis was well known to healers from China and India thousands of years ago; Greek and Roman doctors during classic times; Arab doctors during the Middle Ages; Victorian and Continental physicians in the nineteenth century; American doctors during the early twentieth century; and English doctors until 1971 when a variety of nonevidence-based remedies were removed from the British Pharmaceutical Codex. However, cannabis-based or cannabis-derived medicines have been almost entirely absent from American medicine and barely present in European and Asian pharmacopeias during the twenty-first century .
Dronabinol (Marinol) is the only cannabinoid-based medicine that is approved by the US Food and Drug Administration, with an indication for loss of appetite associated with weight loss in patients with AIDS and those receiving chemotherapy . Dronabinol is the synthetic active enantiomer of the plant-derived cannabinoid, Δ 9 -tetrahydocannabinol (THC) and works via cannabinoid type 1 (CB1) and type 2 (CB2) receptors (CB1R and CB2R, respectively), where it acts as a partial agonist . In more than 20 European and other countries outside the US, nabiximols (Sativex; GW Pharmaceuticals, Cambridge, UK) is approved to treat spasticity in patients with multiple sclerosis . Nabiximols is a mixture extracts of two varieties of the cannabis plant, one predominantly containing THC and the other cannabidiol (CBD). Interestingly, and contrary to popular misconception, CBD is not a potent ligand at either CB1R or CB2R, although occasionally it can functionally modulate the consequences of mammalian endocannabinoid system stimulation in which the 2 cannabinoid receptors play a pivotal role . In fact, CBD has several noncannabinoid receptor molecular targets and thus exemplifies the diverse pharmacology of the 500 discrete components of the cannabis plant, of which nearly 100 have cannabinoid-like chemical structures.
The relative scarcity of proven cannabis-based therapies is not due to data that show that cannabinoids are ineffective or unsafe, but rather reflects a poverty of medical interest and a failure by pharmaceutical companies arising from regulatory restrictions compounded by limits for patent rights on plant cannabinoid-containing preparations that have been used medicinally for millennia, as is the case for most natural products. In some Western countries, funding to study, establish, and prevent adverse effects of recreational cannabis use, such as addiction and cognitive and behavioral disorders, has far outpaced basic or clinical scientific research in this area. This is not surprising, as in the USA, funding by the National Institute of Drug Abuse on research into cannabis abuse has dramatically exceeded that into cannabis therapeutics by all other National Institutes of Health institutes combined , despite the societal change favoring the deregulation of recreational cannabis use in the USA.
We hope that this issue of Neurotherapeutics will serve to mark the bounds of verifiable scientific knowledge of cannabinoids in the treatment of neuropsychiatric and neurological disorders. At the same time, our contributors have also helped identify areas for future research, as well as the strategies needed to move our base of knowledge forward. We hope that this volume will help to accelerate the pace of the appropriately focused and productive research and double-blind placebo-controlled randomized trials to the point at which the care of patients is informed by valid data and not just anecdote.
Phytocannabinoids—cannabinoids synthesized by plants—have a diverse range of biological effects from calcium homeostasis to antioxidant and anti-inflammatory properties and many more . Scientific interest in the pharmacology of cannabis constituents has steadily grown over the last 50 years since the isolation and synthesis of THC and CBD (isolated in 1940, characterized in 1963, and synthesized in the late 1960s) [8–11]. The action of THC at CB1R and the endocannabinoid system [including CB1R and CB2R, their endogenous ligands (the endocannabinoids), and metabolic enzymes for endocannabinoid biosynthesis and inactivation] were discovered in the late 1980s and early 1990s, and has been the most intensively studied aspect of cannabis pharmacology [12, 13]. A PubMed search (May 2015) identified 19,095 references on ‘cannabinoid’, 13,919 on ‘cannabis’, 6740 on ‘endocannabinoid’, 6579 on THC, and 1351 on CBD. These results suggest a wealth of information in the scientific and medical literature, but the vast majority is from basic science using in vitro or animal studies, which justifies caution if effects are being extrapolated to humans. The clinical data on cannabis therapeutics are meager and the vast majority are formed by surveys or small studies that are underpowered and/or suffer from multiple methodological flaws, often by virtue of limited research funding for nonaddiction-focused studies. Thus, we know relatively little about the clinical efficacy of cannabinoids for the various neurological disorders for which historical nonscientific and medical literature have advocated its use.