The ECS is responsible for regulating many of our homeostatic control processes. In other words, this network controls the balance of various systems and organs in the body, including the liver.
Liver fibrosis is a common result of chronic liver damage caused by binge drinking. It can lead to cirrhosis and liver failure.
CBD Oil for Viral Hepatitis
CBD ensures the proper functioning of a system that balances us. So while it won’t cure fatty liver disease, it can prevent its development. And should the disease occur, it may be able to reduce the inflammation in the organ, protecting it against further damage.
With 1,500 mg of CBD taken for a six-week period, no dangerous side effects were observed (1).
Human studies that have examined the safety of different doses of CBD have found no negative effects at the recommended maximum daily dosage of 20 mg/kg. This dosage was taken from the trial of Epidiolex, a CBD-based pharmaceutical for treatment-resistant seizures. To put that in context, an individual weighing 150 pounds would need to take over 1,300 mg of CBD per day, which is way above what most people take (10–80 mg daily).
Epidiolex is made by a pharmaceutical company called GW Pharmaceuticals, who has taken great pains to corner the market on cannabis. In fact, they routinely lobby for stricter regulations that only they can meet, for example, they have pushed for legislation making it harder for medical cannabis companies to be marketed unless FDA approved. So, pushing researchers to find an issue with liver toxicity can only serve to benefit them by allowing them to be the only company able to provide a product that potentially will NOT elevate enzymes when used as directed. By raising consumer skepticism and fear of cannabis, they can effectively corner the market.
To conduct the experiment, scientists fed mice single doses of CBD ranging from “low” at 246 mg/kg up to a mega-dose of 2460 mg/kg CBD. To break it down, for every kilogram of body weight, they gave the mice about 2.5 grams of CBD. This dose is over ten times the normal dose – which is unreasonably high, and which caused the study to be skewed away from reasonable use from the start. The study’s abstract also presents math that is impossible. Since only 6 mice were studied, 75 percent of mice would have been 4.5, leaving only 1.5 mice to survive. Perhaps it is the animal lover in me, but I do hope that whichever mouse was able to survive in two halves is living a healthy life to this day, but something tells me that this figure is simply incorrect.
Dr. Richter also notes that most medications, including Tylenol, raise liver enzymes, and when given extremely high doses of these common medications (or small doses over long periods of time) liver damage can occur. However, research has not shown that life-long use of cannabis has an adverse effect on the liver. In fact, it has shown the opposite, because elevated liver enzymes cease as soon as cannabis leaves the system (unlike dangerous pharmaceuticals) and CBD can be tolerated in dogs at very high dosages without fatal side effects.
Why would the makers of Epidiolex want negative results?
Dr. Gary Richter, a holistic veterinarian and owner and medical director of Holistic Veterinary Care in Oakland, CA, has been using medical cannabis to treat dogs and cats in his practice for years. After years of research, Dr. Richter has spoken publicly about this study and shares that your pet cannot overdose on CBD, and elevated liver enzymes were reported incorrectly.
“Life-threatening risks for dogs from medical cannabis are exceedingly rare,” Richter says. “Toxicity more often occurs when a pet has eaten a product that contains chocolate, coffee, or raisins. Even if the THC toxicity is not excessive, they can sometimes have problems due to these other ingredients.”
One of the questions my team and I are asked often is whether CBD is safe and if it has any negative effects on pets. Because of a recent study, a stern warning from the FDA, and negative coverage in mainstream media outlets, the question has been posed: does cannabidiol, or CBD, elevate liver enzymes to dangerous levels? To find out the truth, I consulted the country’s top holistic veterinarians and did a little digging to explain what this means.
Studies have shown that CBD is actually safer for dogs than many prescription medications, like phenobarbital. In a study conducted by Colorado State University, 10 mg/kg/day or 20mg/kg/day was administered to dogs for 6 days. CBD was tolerated in the study population. There was an elevation in serum ALP in 36 percent of patients, and all other blood parameters were normal – nothing more than a reaction to normal over the counter medications. Six of the 30 dogs had vomiting, and all had mild diarrhea. 11 of 30 dogs experienced erythema of pinna and 10 of 30 dogs experienced nasal and ocular discharge. These effects were significantly safer than many side effects of both over the counter and prescription medications.
As determined by the studies done on Epidiolex®, CBD is metabolized by the liver. People with nonalcoholic steatohepatitis (NASH) are encouraged to limit over-the-counter (OTC) medications to avoid stressing the liver.
What is CBD oil?
How does it impact the liver?
Cannabidiol oil is extracted from the hemp plant, which is in the same family as marijuana. Unlike THC in marijuana, CBD does not cause a “high” or chemical dependence. CBD that is extracted from the hemp plant is legal, but individual states have laws to regulate it.
Because CBD oil is not considered a drug, it can be a common additive in many products. This includes e-cigarettes (vape oil), lotions and various herbal supplements. It has also been shown to relieve symptoms of different disorders like epilepsy, anxiety and multiple sclerosis.
Note, the study cited in the article was very small with children under physician care but if you are a liver patient it is a cautionary note if you are considering CBD oil. We are not aware of any research that would suggest using it more broadly but consult your doctor.
How much CBD is too much?