Some dosages that have been used in research studies for different conditions include:
Topical applications may produce localized effects, but they are unlike to have any mental health benefits.
While CBD is generally well-tolerated, this does not mean that you won’t experience any side effects.
CBD is just one of hundreds of different compounds found in the cannabis plant. While cannabis has been used in holistic medicine for many years, only recently have researchers begun to explore some of the medicinal purposes for CBD and other cannabinoids.
Other CBD products are not FDA regulated and do not have officially recommended dosages. This can make it difficult to determine how much you might need, but there are some things you can consider that might help.
A small clinical study (N= 20) evaluating CBD 10 mg orally or placebo twice daily in patients with moderately active Crohn disease reported no effect, possibly due to a lack of effect by CBD, the low CBD dose used, and/or the small number of participants.Naftali 2017 Further clinical studies in Crohn disease and inflammatory bowel disease are being conducted, with publication of results pending.NIH 2018
CYP3A4 inhibitors (strong): CYP3A4 inhibitors (strong) may increase the serum concentration of cannabidiol. Monitor therapy.Epidiolex June 2018, Stott 2013, Watanabe 2007
Limited experiments in nonobese diabetic mice treated with CBD demonstrated reductions in incidence and manifestations of type 1 diabetes.Di Marzo 2011, Zuardi 2008
CYP2C19 inducers (strong): CYP2C19 inducers (strong) may decrease the serum concentration of cannabidiol. Monitor therapy.Epidiolex June 2018, Jiang 2011, Stott 2013
Limited studies have evaluated the efficacy of CBD alone in generalized social anxiety disorder (1 study) and psychosis (2 studies). A review deemed the studies to be of lower quality or with potential for bias.Whiting 2015 Clinical trials evaluating CBD alone in the management of Prader-Willi Syndrome are being conducted.NIH 2018
Avoid use. Information regarding safety and efficacy of CBD in pregnancy and lactation is limited. The endocannabinoid system plays an role in regulation of fertility; cannabis use and/or disruptions to the endocannabinoid system have demonstrated negative effects on reproduction.Dekker 2012, Karasu 2011, Lewis 2012
The uses described in the following sections focus on CBD specifically. See also Cannabis monograph for further information regarding potential uses of other cannabinoids.
Ultimately, the study sample is too small to draw definite conclusions on CBD as a treatment for psychosis patients as a group. The study also doesn’t look at how brain activity changes matched up to behavior in the participants with psychosis — which means we can’t know if CBD improved their performance on the memory tasks.
The study included a group of 13 people with a diagnosis of psychosis and 16 people without the disorder. The participants were asked to perform three different verbal-association memory tasks (such as deciding whether words were paired in a logical way, and recalling which words they’d previously seen paired, or what font they were in) while in an fMRI machine.
The single dose of CBD appeared to diminish the differences in activity in the brains with psychosis and those without. For example, during memory exercises like recalling something verbally, a brain affected by psychosis has abnormal activity such as greater connectivity in the front of the brain (prefrontal, mediotemporal and striatal areas), which makes it harder to recall things logically. But after taking even just a single dose of CBD activation in these areas tended to look similar to that of a person without the condition.
CBD and brain activity
The results suggest that CBD could offer a treatment for the memory problems associated with psychosis, a common mental-health condition that affects 20 million people worldwide, according to the World Health Organization.
The results build on a 2018 study from the same team suggesting that CBD can normalize brain activity in people with symptoms of psychosis. This new study takes the work forward by including people with a clear diagnosis.
Those with psychosis were already on standard antipsychotic treatment at the start of the study, and they continued on the treatment throughout the study. After taking scans of their brains to establish baseline activity, the researchers then gave each participant a placebo drug and then 600 mg of CBD, and rescanned their brains.
Scientists compared brain scan results of people with a diagnosis of psychosis and people without the disorder as they were doing a memory exercise. In the people with psychosis, the researchers found clear differences in the activity patterns in their prefrontal, mediotemporal, and striatal areas of the brain — those that regulate decision making, learning and memory. But when these participants were given a single dose of CBD, their brain activity patterns were more similar to those of people without the disorder.