To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have roughly 600 drops. If the concentration of the tincture is 1,500 mg/mL, one drop would contain 2.5 mg of CBD (1,500 mg ÷ 600 drops = 2.5 mg).
Remember, because CBD oils are largely unregulated, there is no guarantee that a product is either safe or effective.
In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under 2—Dravet syndrome and Lennox-Gastaut syndrome. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
How to Calculate CBD Dose
Potential drug-drug interactions with CBD include:
Medical marijuana is frequently prescribed to people with intractable (treatment-resistant) pain, including those with terminal cancer. There is some evidence that CBD contributes to this benefit.
However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.
Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD’s distinct effects.
Just as hemp seedlings are sprouting up across the United States, so is the marketing. From oils and nasal sprays to lollipops and suppositories, it seems no place is too sacred for CBD. “It’s the monster that has taken over the room,” Dr. Brad Ingram, an associate professor of pediatrics at the University of Mississippi Medical Center, said about all the wild uses for CBD now. He is leading a clinical trial into administering CBD to children and teenagers with drug-resistant epilepsy.
But he cautions that the side effects could have been because of an interaction with other medications the children were taking to control the seizures. So far, there hasn’t been a randomized, placebo-controlled, double-blind trial (the gold standard) on sleep disorders and CBD.
Is This A Scam?
“If you take pure CBD, it’s pretty safe,” said Marcel Bonn-Miller, an adjunct assistant professor at the University of Pennsylvania’s Perelman School of Medicine. Side effects in the Epidiolex trial included diarrhea, sleepiness, fatigue, weakness, rash, decreased appetite and elevated liver enzymes. Also, the safe amount to consume in a day, or at all during pregnancy, is still not known.
Cannabis containing 0.3 percent or less of THC is hemp. Although last year’s Farm Bill legalized hemp under federal law, it also preserved the Food and Drug Administration’s oversight of products derived from cannabis.
Up in the wee hours of the night, stuck watching videos of puppies? CBD may be promising as a sleep aid; one of the side effects of the Epidiolex trials for epilepsy was drowsiness, according to Mr. MacKillop, a co-author of a review on cannabinoids and sleep. “If you are looking for new treatments for sleep, that may be a clue,” he said.
CBD has become so widely used in part because early research suggests that it may offer possible health benefits—potentially reducing pain and anxiety, for example.
In dozens of states, health food stores, pharmacies, and even supermarkets and restaurants are carrying CBD products. That includes pills, oils, balms, vaping devices (like e-cigarettes), and edibles, including gummy bears, honey, coffees, and alcoholic beverages, among others.
Cannabidiol, touted for its many possible health benefits, is in pills, creams, and even salad dressings and honey
Even with so many unknowns about CBD’s effectiveness, retailers are popping up across the country. Tia Tagliaferro is chief operating officer for Hemp Garden, which sells hemp-based CBD products at its stores in New York City and Wilmington, N.C. She says the potential healing benefits of CBD and its popularity are what spurred the company to open its latest shop in New York earlier this summer, with plans to expand into other East Coast locations in the coming months.
Vape pens are easy to use and can go undetected because they produce little smoke, Raiman says. (Note that Oregon and certain other states have laws that prohibit vaping in the same places where smoking cigarettes is prohibited.)
Pros: Inhaled CBD tends to enter the bloodstream faster than other forms—in as quickly as 30 seconds or less, according to Mitch Earleywine, Ph.D., a professor of psychology at the State University of New York, Albany, and an adviser to the marijuana advocacy group NORML. He is also the author of “Understanding Marijuana” (Oxford University Press). The quick action means it should affect the body sooner, which could be especially useful to ease immediate pain or anxiety, for example.