So theoretically, reducing the breakdown of testosterone may offset reductions in synthesis. But thats just speculation at this point. Also, these studies show a decrease in testosterone at high doses used mid term.
We need insulin to tell our cells when to take in sugar from the bloodstream. Healthy insulin levels mean we use sugar effectively in our muscles and liver, and don’t store too much in fat tissue.
Endocannabinoids on the other hand encourage the sparing and storage of energy, in part by reducing thyroid hormones (1) .
Estradiol E 2 ( Estrogen)
Some of the major roles of hormones are:
Its mainly synthesised in the testes and ovaries, and is made in repose to hormonal signals from the hypothalamus (LH and FSH).
A few benefits of increased growth hormone output are:
There are three main ways that CBD can change how hormones work in the body.
Various water-insoluble cannabinoids as well as SP-111A, the water-soluble derivative of delta 9-tetrahydrocannabinol (delta 9-THC), reduced hCG and dibutyryl-cAMP stimulated testosterone production by rat testicular Leydig cell preparations. With 0.15 microM (0.05 micrograms/ml) 8-beta-OH-delta 9-THC the inhibition was about 50% of stimulated testosterone synthesis. Dose-related inhibitions were apparent with other cannabinoids and their order of potency in inhibiting stimulated steroidogenesis by the interstitial cells in vitro was found to be: 8-beta-OH-delta 9-THC greater than or equal to 11-OH-delta 9-THC greater than CBN = CBD = CBG greater than or equal delta 9-THC = delta 8-THC. The non-stimulated, basal, steroidogenesis was not affected even with 15 microM cannabinoids. The incorporation of L-[U-14C]leucine into the protein of Leydig cells was markedly reduced by 15 microM cannabinoids under both basal and stimulated conditions. The inhibition of steroidogenesis as well as protein synthesis in rat testicular Leydig cell preparations by various cannabinoids cannot be correlated with their psychoactivity. The present data suggest that cannabinoids at very low concentrations may interfere directly in Leydig cells with both protein and testosterone synthesis, and thus with their function.