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The endocannabinoid (EC) system helps the body manage anxiety, inflammation, and other physiological responses to different forms of stress. Copaiba Oil, similar to Black Pepper, has a soothing aroma and, when taken internally, supports a healthy cardiovascular, immune, digestive, and nervous systems.†

Endocannabinoids Explained

In this article, we review the endocannabinoid system and the effects of tetrahydrocannabinol (THC), Cannabidiol (CBD), and Beta-caryophyllene (BCP).

The endocannabinoid system

The endocannabinoid (EC) system helps the body manage anxiety, inflammation, and other physiological responses to different forms of stress. During strenuous exercise, stress, and other related stimuli, the body produces compounds called endocannabinoids. Endocannabinoids (ECs) are signaling molecules that trigger the activation of the EC system when they are detected by cannabinoid receptors.

Cannabinoid receptors (CRs) not only detect the presence of ECs, but they are also affected by molecules from outside sources that chemically resemble endocannabinoids. The term cannabinoid refers to any compound, produced by the body or from an outside source, that triggers the EC system by activating CRs. Anandamide is an EC compound produced in the body. Anandamide activates two types of CRs, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).

A “runner’s high” is a perfect example of the EC system at work. After a long period of strenuous exercise, the body begins to produce anandamide in order to activate CRs and turn on the EC system. The “runner’s high” has two components: slight euphoria, and soothing of the discomfort in the muscles and joints. These two outcomes are linked with two distinct structures: the CB1 and CB2 receptors. CB1 receptors are mainly found in the brain and central nervous system, and are linked with pleasure and reward pathways. CB1 receptor activation leads to feelings of euphoria. CB2 receptors are found in the rest of the body, like the muscles, skin, and vital organs. They are mainly found on the surface of white blood cells, and their activation affects the regulation of inflammation chemicals called cytokines.

THC & CBD

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THC is the main psychoactive compound in marijuana. According to GC/MS analyses conducted by doTERRA’s analytical chemists, it is found in high concentrations in many brands of cannabis oil, and it can also be found in hemp and CBD oil in more than just trace amounts. THC is known to activate both CB1 and CB2 receptors. It is generally accepted as a potent drug with powerful psychoactive properties.

CBD, another compound found in high quantities in marijuana, CBD oil, and hemp oil, does in fact interact directly with CB1 and CB2, but the interaction is so weak as to be negligible. 2 CBD actually exerts its effects on the EC system by a different mechanism than most cannabinoids.

Research shows that CBD acts on the enzyme FAAH, which breaks down anandamide. CBD actually slows down the enzyme’s activity, which leads to increased levels of anandamide in the body. 1 The reason why this is significant is because anandamide interacts with CB1 and CB2 receptors. Higher levels of anandamide would result in increased feelings of euphoria due to increased activation of CB1 receptors, as well as soothing of the tissues due to activation of CB2.

CBD, by increasing levels of anandamide, has similar pharmacological effects as THC in that it affects the same two cannabinoid receptors, however the magnitude of the effect is much smaller compared with THC. CBD is generally considered non-hallucinogenic.

BCP

Soothing the tissues without triggering any sort of psychoactive response can be accomplished by using a compound with selective interaction with the CB2 receptor. Beta-caryophyllene (BCP) is a sesquiterpene compound found in hundreds of different plant species, and it has recently been recognized for its unique ability to interact with CB2 but not CB1 receptors. 3 Thus the alleged benefits of CBD or THC can be obtained without the psychoactive effects by using a product containing BCP. doTERRA’s new Copaiba essential oil has the highest BCP content of any oil, around 55% as confirmed by GC/MS analysis of doTERRA’s own Copaiba oil.

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There is ample evidence pointing to the benefits of oral supplementation of beta-caryophyllene, but like CBD and hemp oil, further research in the form of human clinical trials is required. More promising are the low doses at which some of these studies have been conducted. These dosages suggest that as little as 1-2 drops of Copaiba oil or 3-4 drops of Black Pepper oil may provide noticeable results in humans. At this time, the systemic soothing properties of beta-caryophyllene have potential benefit as treatment for a wide range of health issues.* Still unexplored are the effects of CB2 receptor activation on human diseases for which there are few experimental models—such as learning disabilities and autism spectrum disorders—that many claim can benefit from using cannabis.

Conclusion

To summarize, there are many ways to modulate the body’s cannabinoid system. Products containing CBD, THC, and BCP all affect the endocannabinoid system. We acknowledge that health care professionals may recommend different products containing different kinds of cannabinoid compounds for different health issues. However, at doTERRA we believe that BCP-containing products are the most effective for healthy individuals seeking a product that they can use for self-care.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Copaiba Essential Oil

Copaifera reticulate, officinalis, coriacea, and langsdorffii

Powerfully relaxing, Copaiba oil comes from a fragrant tropical tree native to South America. Copaiba oil can help soothe anxious feelings and supports the cardiovascular, nervous, digestive, immune, and respiratory systems.*

Copaiba Essential Oil Usage Tips:

  • Add one to two drops of Copaiba oil to water, juice, or tea to support the health of the cardiovascular, immune, digestive, nervous, and respiratory system.*
  • Copaiba oil Provides antioxidant support when ingested.*
  • Drop one to two drops of Copaiba oil under the tongue as part of your daily health regimen.
  • Add a drop of Copaiba oil to facial moisturizer to help keep skin clear and reduce the appearance of blemishes.
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Learn More About Copaiba Essential Oil

What Is Copaiba Essential Oil?

The Copaiba is a large towering tree that grows in tropical rainforests of South America. For hundreds of years, traditional healers in northern Brazil have used copaiba trees for their health benefits. Copaiba oil is steam distilled from the resin of the tree.

What Is Copaiba Essential Oil Used For?

Copaiba oil supports the health of the cardiovascular, nervous, digestive, immune, and respiratory systems.*

doTERRA Copaiba oil is sourced in Brazil from four species of copaiba. By harnessing the benefits of the most potent copaiba species, a maximum potency essential oil is obtained. With a pleasant, spicy, and woody aroma, Copaiba oil can help calm emotions and soothe anxious feelings. It is a wonderful oil to turn to at the end of a stressful day.

Can Copaiba Essential Oil Be Taken Internally?

Copaiba oil also has a plethora of benefits when taken internally. The main constituent of Copaiba oil is Beta-caryophyllene, which is also present in Black Pepper essential oil and helps soothe anxious feelings.* In addition to its emotional benefits, Beta-caryophyllene promotes healthy nervous, cardiovascular, and immune system function.* The oil also contains powerful antioxidants that boost immune health.* Copaiba oil is a well-loved oil because it relieves discomfort and promotes overall health, supporting people to feel and live their best.

Due to its beautifying effect on the skin, Copaiba oil is widely used in cosmetics. To promote a clear, smooth complexion, Copaiba oil may be combined with Cedarwood and diluted with Fractionated Coconut Oil and applied topically.

Can You Diffuse Copaiba Essential Oil?

Diffusing or inhaling Copaiba oil is deeply relaxing and soothing. Add a few drops to a diffuser for emotional support. For increased cellular support, take internally alone or with Frankincense.* For digestive support at mealtimes, take with Peppermint.*

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