CBD should be used according to the manufacturer’s instructions. A person should read and follow the label carefully. Use no more than instructed. Using more may increase the chance of side effects or it may cause other problems.
Two ways to use CBD are by mouth (oral) and applied to the skin (topical).
What Are the Side Effects of CBD?
CAUTION: Since CBD may cause tiredness or drowsiness, people should be very careful when driving, using tools or other equipment, or performing other risky activities.
CBD is not psychoactive; it does not have a mind-altering effect.
Studies are ongoing, but there is evidence that CBD may be effective in reducing anxiety, chronic (long-term) pain like back pain, and insomnia or trouble sleeping.
To avoid interactions, tell your doctor and pharmacist about all prescription, over-the-counter, herbal, or recreational drugs you are taking.
CBD oil is an extract of Cannabis indica or Cannabis sativa—the same plants that, when dried, make marijuana. CBD oil is believed by some to treat pain, reduce anxiety, and stimulate appetite in the same way that marijuana does, but without its psychoactive effects. CBD has also shown promise in treating certain types of seizures.
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.
Dosage and Preparation
In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under 2—Dravet syndrome and Lennox-Gastaut syndrome. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
For this study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. According to the researcher, those treated with CBD had lower blood pressure before and after exposure to stressful stimuli (including exercise or extreme cold).
However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.
Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.