Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5- HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting.
Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor, which is concentrated in the brain and central nervous system. While cannabidiol doesn’t bind to the CB1 receptor directly like THC does, CBD interacts allosterically with CB1 and changes the shape of the receptor in a way that weakens CB1 ’s ability to bind with THC .
Cannabidiol ( CBD ), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD .
Whereas cannabidiol directly activates the 5- HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55 .
CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5- HT1A receptor (even more so than CBD ). Preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC , which also have anti-nausea properties.
Initially, research showed endocannabinoid receptors were only present in the brain and nerves, but have since been found throughout the entire body including our skin.₃ Today we know that the endocannabinoid system is involved in a number of processes including pain, memory, mood, appetite, stress, sleep, metabolism, immune system, and our reproductive function.₄,₅ Endocannabinoids are arguably one of the most widespread and versatile molecules.
Can I take this if I am in antidepressants and suboxone?
Will it make me gain weight?
I struggle with lots of back pain , depression, anxiety and I have hard time sleeping. Will it be helpful?
CBD and your endocannabinoid system
The Endocannabinoid system (ECS) plays a major role in balancing our bodies’ most important functions from sleep, to mood, to appetite, to bowel movements, and more.
“CBD modulates non cannabinoid receptors as well. It directly activates the 5hT (serotonin receptor and acts as an atypical antipsychotic), binds directly to TRPV1 (Pain, inflammation, hypothalamus control). It blocks GPR55 (a 3rd cannabinoid type receptor) which through a series of events, decreases the breakdown of bone, acts as an antiseptic, prevents cancer cells from growing and many other things. CBD also changes the shape of the CB1, preventing THC from directly binding to it. (This is why balanced strains of cannabis give less anxiety and paranoia; the CB1 receptors are not overstimulated by THC.)”
Your body naturally produces its own endocannabinoids to support this system, but just like with any other nutrient, we can have a deficiency and may need extra support. This is where cannabis comes in. The cannabis plant produces phytocannabinoids that also interact with your endocannabinoid system.
CBD (Cannabidiol) is one of over 100 compounds found in hemp and marijuana. It’s the second most prevalent compound (second only to THC) in cannabis. CBD belongs to a class of molecules called phyto-cannabinoids and is non-psychoactive.This is the part of the plant that keeps you healthy, not high.
McPartland JM, Matias I, Di Marzo V, Glass M. Evolutionary origins of the endocannabinoid system. Gene. 2006;370:64-74.doi:https://doi.org/10.1016/j.gene.2005.11.004.
What is CBD?
The human body is a complex machine, and the way it interacts with any compound, including Cannabidiol (CBD) can be even more so. We’ve only known about the system in our body that cannabinoids are part of since the 1990’s so there is definitely so much more to learn! Nonetheless, we’ve compiled and broken down some of the basic science we do know below.
Once manufactured, endocannabinoids attach to cannabinoid receptors. It was initially believed that endocannabinoid receptors only existed in the brain and nerves, but receptors have since been discovered throughout the entire human body, including the skin.
The Endocannabinoid System (ECS), named after the plant that led to its discovery, is perhaps the most important physiological system involved in establishing and maintaining human health. Endocannabinoids are some of the most versatile and widespread molecules. The system plays a major role in balancing many important functions. The endocannabinoid system also isn’t unique to humans. Scientists have found that the ECS exists in any animal with a vertebra, including fish, reptiles, birds, and mammals.