It’s important to note that, while existing evidence shows us that CBD can definitely be detected in the body for a certain period of time, most drug tests specifically look for the presence of THC. Therefore, accurate information on how long CBD stays in the body remains limited compared with information on THC.
Bottom line: Existing evidence suggests that CBD reaches peak blood concentration within three minutes after inhalation, meaning any effects should be felt shortly after use. The effects should then last anywhere from 45 minutes to a couple of hours.
How long do CBD oil effects last?
Bottom line: Whether you’re ingesting CBD oil or CBD-infused edibles, it ultimately goes through the same lengthy digestive process, reducing the total CBD concentration in the bloodstream. With ingestion, it could take anywhere from one to two hours before the effects of CBD finally set in. From there, you may feel the effects for one hour to several hours, depending on the dose and your response to CBD.
Consumers who want to be extra-cautious and use CBD with no THC should shop for a broad-spectrum oil or a CBD product that contains pure CBD isolate. Broad-spectrum oil is refined to exclude THC, while CBD isolates contain no THC or other plant-based cannabinoids. To ensure that your CBD contains no THC, it’s important to source products from reputable manufacturers that provide a certificate of analysis from a third-party testing lab.
Consumers who want to be extra-cautious and use CBD with no THC should shop for a broad-spectrum oil or a CBD product that contains pure CBD isolate. Photo by: Gina Coleman/Weedmaps
The method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.
Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream and circulated throughout the body.
CBD interacts with the brain and body through a number of mechanisms. Upon ingestion, CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS) — specifically the CB1 and CB2 cannabinoid receptors.
CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. Any potential anti-inflammatory and pain-relieving properties of CBD could stem from the activation of these additional biological pathways.
Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system. Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.