• It can make Parkinson's disease worse.
"To date, there is no evidence of public health related problems associated with the use of pure CBD."
According to a report by the World Health Organization, "CBD appears to have little effect on conditioned place preference or intracranial self-stimulation… [It] exhibits no effects indicative of any abuse or dependence potential."
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It can also interact with medications through "the exact same mechanism that grapefruit juice does," according to an article on the Harvard health blog. While rarely a significant concern, on certain medications these interactions can be harmful or even deadly, according to the FDA. If you have blood pressure issues, are taking prescription drugs or have ever been warned about ingesting fruit juice, citrus or fermented products, consult your doctor before touching CBD oil.
Most of the side effects of CBD oil are moderate. Unless you fall into one of the specific categories above, the odds are that this is a generally benign product with limited negative consequences, according to one research paper. Most of those include:
There isn't enough evidence to say that the oil definitely does help with these things, nor that simply cramming some in a milkshake will do the slightest bit of good, just that doctors are optimistic about their research. For more information on the medicine of CBD oil, see our article here.
This side effect should come as no surprise. Doctors have long looked at cannabis as a treatment for sleep disorders, and CBD oil is no exception. Putting you to sleep is a feature, not a bug. Just don't be surprised if your CBD latte doesn't pack the caffeine punch you expected.
Clobazam, used to treat epileptic seizures, is another type of drug that may not be advisable to take in conjunction with CBD. However, Epidiolex is an FDA-approved, CBD-based drug that physicians may prescribe to treat epilepsy. A significant amount of data, derived from clinical trials, exists on Epidiolex, although the drug can also cause adverse effects, according to a 2019 study conducted by researchers at Columbia University and published in the journal F1000Research.
Cannabis is a complex plant, with hundreds of chemicals and over 100 distinct cannabinoids. The little research that examines cannabidiol or CBD, the second most common cannabinoid found in cannabis, shows evidence of potential health benefits for a wide range of conditions. As CBD becomes more mainstream, however, a key question comes to mind, “How will CBD interact with my current medication?”
Acetaminophen, the generic name for Tylenol, is a common drug used for pain and fever relief. Acetaminophen carries a risk of liver damage and disease, with side effects including nausea, headaches, and insomnia.
Does CBD oil affect blood pressure?
These drug classifications include a large percentage of existing prescriptions, such as benzodiazepines, antihistamines, haloperidol, antiretrovirals, statins, cyclosporine, sildenafil, warfarin, and other drugs metabolized by CYP3A4 and CYP2D6.
Xanax breaks down in the liver via an enzyme called CYP3A4, which is inhibited by CBD. Taking CBD could potentially increase the amount of time Xanax is in the system and prolong or increase the likelihood of unwanted side effects. CBD may one day be considered an alternative to Xanax as various research, including a 2011 study published in the journal Neuropsychopharmacology, has documented the cannabinoid’s potential anti-anxiety properties.
Patients should consult with their healthcare provider before taking ibuprofen with CBD.
CBD’s documented effects on liver function and enzymes that metabolize several medications are relevant when considering whether or not to consume CBD with certain drugs. CBD acts on the same metabolites as grapefruit — therefore, many of the prescription drugs that carry grapefruit warning labels may have similar risks when taken with CBD.