Liposomal CBD Oil

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Liposomal CBD may enhance hemp extract—but is it worth the money? In this article, we explore this upcoming area of cannabis research, its uses and potential benefits Liposomal CBD supplements manufactured by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability.

Liposomal CBD – A Breakthrough in the CBD Industry or Waste of Money?

The liposome represents a closed phospholipid bilayer vesicular system. The ability of these systems to encapsulate both hydrophobic and hydrophilic drugs, along with their biocompatibility and biodegradability, makes liposomes attractive tools in the field of drug delivery. Liposomes benefits have led to their widespread use as delivery vehicles for anti-cancer molecules, diagnostics, and therapeutic agents.

Liposomal CBD offers increased bioavailability, better control, and limited toxicity than non-liposomal CBD products. Liposomal delivery significantly reduces cannabidiol breakdown by metabolic processes allowing more CBD to enter the bloodstream. As a result, lower doses of liposomal CBD products may help achieve the same effects as higher doses of non-liposomal options. However, liposomal cannabidiol research is limited, and we need more information about its safety and efficacy.

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Introduction

CBD or cannabidiol is considered an incredibly versatile cannabinoid with potential soothing and relaxing properties. To date, experts believe cannabinoids and terpenes are the most promising compounds in Cannabis plants, especially Cannabis Sativa and Cannabis Indica. The medicinal use of cannabinoids may provide replenishing effects. Cannabis specialists attribute some well-being benefits to one cannabinoid, while other uses may come from a combination of cannabinoids isolated from the cannabis plant. Ongoing research of cannabinoids and terpenes reveal new potential benefits of these natural compounds for wellness.

Some people use raw (or unheated) phytocannabinoid components like cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA) to benefit their well-being. In contrast, others may use the heat treatment of the plant extract to convert carboxylic acid forms of these components to their decarboxylated versions like CBD or THC by removing a carboxyl group and releasing carbon dioxide (CO2).

To date, cannabinoids are in all cannabis preparations. These compounds of the cannabis plant as direct agonists may bind to cannabinoids receptors in the brain to produce their effects. Cannabinoid receptors are one of the three main components of the endocannabinoid system or ECS—a complex cell-signalling system. The ECS regulates a range of physiological, cognitive, and homeostatic functions, including immune function, discomfort, appetite, metabolism, energy balance, memory, mood, and neurogenesis.

Besides two types of cannabinoid receptors (CB1 and CB2 receptors), the ECS also consists of endogenous cannabinoids. Some of these include anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and metabolic enzymes including fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Endogenous cannabinoids may bind as agonists to cannabinoid receptors, which are widely distributed throughout the brain and have high concentrations in reward and pain-related neural circuits. As for phytocannabinoids, like CBD and THC, these compounds may interact with the ECS by binding to its receptors like endocannabinoids. They potentially impact the way the ECS functions.

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Nowadays, medical professionals consider CBD a breakthrough in medicine as this compound, along with other cannabinoids and terpenes in the cannabis plant, shows great promise for aiding holistic well-being. Due to this, global research on the potential benefits and side effects of cannabinoids is ongoing. Scientists worldwide are working to create the most effective and safe compound, hoping it will work along with existing medications and potentially substitute some of them in the future.

Liposomal CBD is the novel format of CBD oil, which some experts believe to be more effective than other oral CBD products. Let’s check what the research says and determine whether it is worth the money or another publicity stunt.

What are Liposomes? Benefits of the Liposomal Delivery System

The Greek etymology of liposome is “lipos”, meaning fat and “soma”, which means body. Liposomes are microscopic spheres surrounding nutrients or medicine, supporting their absorption into the body. A liposome is a “bubble” that packages a drug to protect it from normal bodily processes like digestion. Liposomes typically use phospholipids—materials, which are the same molecules that make up the cell membranes of our body. Phospholipids can aid direct drug absorption and bypass regular digestive system functions. The liposomal delivery system was first coined in the 1960s to improve the delivery of vital nutrients and medicines into the body. Currently, this system is primarily used in cancer treatments and is considered one of the most scientifically advanced drug delivery methods on the planet.

Specialists from the National Cancer Institute state that liposomes represent a drug preparation that contains the active drug inside tiny, fat-like particles. Due to its small size, it is easier for the body to absorb these particles, allowing more of the drug to get to the target area, such as a tumour. Moreover, liposomal drugs may have fewer side effects and work better than other drug forms. Experts in this field suggest that any substance can utilise the liposomal delivery system so long as the active compounds are encased in a tiny fatty vesicle. However, researchers state this method works best with fat-soluble substances or minerals.

CBD is fat-soluble and works excellent in liposomal form. This form of CBD delivery enhances its bioavailability, increasing its absorption level in the body’s cells, tissues, and organs. In this way, consumers get the most from their CBD.

Bioavailability of Liposomal CBD Products: Can Small Size Trick Metabolic Processes?

The bioavailability can be comparable to the efficiency of the drug as this term describes the relative fraction of the orally administered dose, which is absorbed into the bloodstream. In other words, bioavailability is the amount of drug or any other substance the body can actually “use”. Bioavailability is usually represented as a percentage and calculated by comparing a systemic exposure profile to a suitable reference product.

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The bioavailability of any drug (or substance) depends on how you introduce it to the body. For example, intravenous drug administration provides 100% bioavailability as all of it enters the bloodstream. At the same time, when taking a substance orally or in any other way, bioavailability starts decreasing as metabolic and digestive processes break down the compounds we ingest.

When it comes to CBD, different methods of taking this cannabinoid provide different bioavailability rates. To date, oral CBD formulations like capsules, foods, and beverages are among the most popular ways to consume CBD. However, this form of cannabidiol has the lowest bioavailability compared to other delivery forms. On average, oral CBD products can provide us with 6-19% bioavailability. Digestive acids and enzymes destroy a large percentage of CBD before its absorption, allowing only a small amount of the product to get through the intestinal wall, where the liver metabolises it and eventually reaches the rest of the body.

The industry considers CBD vaping and smoking more efficient as, in such a case, CBD bypasses the digestive tract and liver, which allows it to be readily absorbed through the thin membranes lining the alveoli of the lungs where it goes directly into the bloodstream. Smoking and vaping CBD have a bioavailability of 31%, but vaping may be the less irritating inhalation form. Unlike vaping, smoking produces combustion by-products such as fluorene, pyrene, acrylonitrile, and acrylamide, which may irritate the lungs.

Sublingual CBD drops and sprays allow cannabidiol to be absorbed through the mucous membranes of the mouth and nose, bypassing metabolic and digestive processes and going straight to the bloodstream. The sublingual method is most effective with liquid products like oils or tinctures and can provide consumers with up to 35% bioavailability which is significantly better than just swallowing CBD. Holding the drops under the tongue for 20-30 seconds before swallowing may improve CBD absorption.

Topical cannabidiol products like CBD-infused creams, lotions, and balms have the lowest bioavailability rates as fat-soluble cannabidiol is repelled by the water-soluble layer of skin which acts as a barrier to absorption. However, transdermal CBD provides a slow and steady absorption of the cannabinoid into the body, allowing its entrance into the bloodstream and maintaining its consistent level in the blood.

What about liposomal CBD? This form of CBD increases the bioavailability and allows the cannabinoid to stay longer in the body beyond the metabolic processes giving it time to absorb into the bloodstream. A pilot study investigated liposomal cannabidiol delivery and compared it to non-liposomal CBD when individuals consume them orally. Study results demonstrated that 40% of the study participants who took the non-liposomal form of cannabidiol had CBD in their blood one hour after ingestion. In comparison, all of the patients (100%) who took the liposomal CBD had it in the blood after the same period. These results demonstrate that liposomal cannabidiol has significantly better bioavailability than its stand-alone form. Limited research exists on the improved bioavailability of liposomal CBD, although studies are ongoing.

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Liposomal CBD products may help cannabidiol bypass the digestive system, where its bioactive compounds break down or the body rejects them. Researchers state that compounds like cannabidiol need a little help getting into the bloodstream, and liposomes can handle this successfully. It’s necessary to invest more time and research to better understand the peculiarities of the physiological CBD components and how they function with liposomes on a molecular level. To date, CBD liposomes are a unique concept in the cannabidiol industry. Experts believe that hemp oil liposomes may become a significant boost to the overall cannabis industry and be a great way to ensure that natural hemp compounds deliver effectively and efficiently.

Liposomal CBD

Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects [1].

Highly effective

Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.

Science Based

Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.

Better efficacy
Non-toxic

Our liposomes are essentially non-toxic and biologically degradable.

Why Liposoma’s Liposomal CBD?

CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products [2].

Liposomal CBD

To make sure that CBD arrives in the gut in its active form, a solution is to incorporate it in liposomes, which are small, carefully designed phospholipid vesicles that form very stable dispersions in water [3]. The phospholipids constitute a bilayer structure in which the CBD molecules can be safely kept dissolved, while at the same time they act as surfactants that help present them to the intestinal epithelial cells in the most optimal manner.

What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes.

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