Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. There is a growing body of preclinical and clinical evidence to support use of CBD oils for many conditions, suggesting its potential role as another option for treating challenging chronic pain or opioid addiction. Care must be taken when directing patients toward CBD products because there is little regulation, and studies have found inaccurate labeling of CBD and tetrahydrocannabinol quantities. This article provides an overview of the scientific work on cannabinoids, CBD, and hemp oil and the distinction between marijuana, hemp, and the different components of CBD and hemp oil products. We summarize the current legal status of CBD and hemp oils in the United States and provide a guide to identifying higher-quality products so that clinicians can advise their patients on the safest and most evidence-based formulations. This review is based on a PubMed search using the terms CBD, cannabidiol, hemp oil, and medical marijuana. Articles were screened for relevance, and those with the most up-to-date information were selected for inclusion.
Copyright © 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
The effective dosage for personal use; the CBD is treated as a supplement. When you start your intake with CBD oil, start with a few drops a day, or a capsule of a few milligrams. Wait a few days and see how you feel. The CDB assay aims to reach the point requested by your endocannabinoid system. It is better to start small and gradually increase the doses. For example, take 3 doses at 10% per day for 1-2 weeks, then, if necessary, increase the first week take 1 dose at 20% then 2 to 10%, the second week go to 2 doses 20% and 1 to 10% to reach 3 doses 20% the third week. If you feel the need to increase the doses, it is recommended to do so gradually in one-week cycles.
Schizophrenia: 40-1,280 mg CBD by mouth every day for up to four weeks.
Chronic pain: 2.5 to 20 mg of CBD orally for an average of 25 days
Symptoms of multiple sclerosis: Cannabis plant extracts containing 2.5-120 milligrams of THC-CBD per mouth daily for 2 to 15 weeks. Consumers generally use eight shots within three hours, with a maximum of 48 sprays in 24 hours.
Appetite for cancer patients: 2.5 milligrams of oral THC with or without 1 mg CBD for six weeks
According to CannLabs, the comprehensive testing laboratory for cannabis products, there is no lethal dose of CBD. CBD has no known adverse side effects at any dose. But drug interactions can be problematic. Consumers should carefully read the product inserts to ensure that they are taking the correct amount of CBD. And if possible, they should contact the attending physician with any questions or concerns.
Epilepsy: 200-300 mg of CBD by mouth every day for up to 4.5 months.