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negative effects of cbd oil

Common symptoms include:

CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.

Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.

Possible Side Effects

Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.

There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.

Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.

CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.

Wendy Rose Gould is a lifestyle reporter with over a decade of experience covering health and wellness topics.

Because CBD supplements come in so many different forms—such as oils, gummies, tinctures, and vapors—the amount that’s actually absorbed can vary drastically. This, combined with each person, will ultimately affect which (if any) CBD side effects you might experience.

Common Side Effects of CBD

CBD—the abbreviation for cannabidiol, a substance that’s generally derived from the hemp plant—has skyrocketed in popularity over the last five years. In fact, according to some research, “CBD” as a Google search term remained stable from 2004 to 2014 but has since ballooned by up to 605%.

Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.

It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.

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Special Precautions and Warnings

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Singh RK, Dillon B, Tatum DA, Van Poppel KC, Bonthius DJ. Drug-Drug Interactions Between Cannabidiol and Lithium. Child Neurol Open. 2020;7:2329048X20947896. View abstract.

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