The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).
CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.
How to Calculate CBD Dose
To use CBD oil, place one or more drops under the tongue and hold the dose there for 30 to 60 seconds without swallowing. Capsules and gummies are easier to dose, although they tend to be more costly. CBD sublingual sprays are available as well.
Common symptoms include:
Here are a few tips to help you find the best CBD oil:
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.
Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.
“CBD is not an intoxicating substance, whereas THC is a psychoactive that can get you high,” explains Dr. Jas Matharu-Daley, a physician and consultant for a brand that specializes in CBD production.
Are There Any Benefits Associated With Using CBD?
“If the CBD is from a reputable source and one that has been inspected by a third-party independent lab, the content of CBD is more reliable,” notes Dr. Matharu-Daley. “The CBD should be organically grown, free of pesticides and heavy metals, and not sourced in food which can affect absorption. Generally, CBD is safe and side effects are few at low doses.”
She adds, “[Another difference is that] CBD is derived from hemp and has been classified as a legal substance. Hemp has <0.3% THC. Conversely, cannabis plants such as marijuana are grown to have much higher levels of THC and are still illegal according to the FDA, although individual states vary as to their use.”
CBD is technically an unregulated substance in the United States and therefore it ought to be used with caution. This is especially important for those taking additional medications and/or those with ongoing medical issues. That said, preliminary research on CBD and its benefits are promising in relation to helping with mild to moderate health concerns and it is generally considered a safe substance. Health professionals do not consider CBD a cure-all for serious medical issues, including cancer.
CBD benefits include the following:
The body also produces natural cannabinoids, called endocannabinoids. Cannabinoids act on cannabinoid receptors.
Early research on CBD for the treatment of insomnia suggests that it may be effective. Additional studies are needed.
How does CBD work?
Applications of transdermal cannabidiol were studied in people with temporomandibular (joint of the jaw) disorders (TMD) that caused myofascial (coverings of muscle) pain. Those studied had less muscle activity and pain after applying the topical CBD for 2 weeks.
There are also studies of oral, topical, and inhaled CBD for use in many other conditions including: dystonia (movement disorder), Fragile X syndrome (rare genetic disorder), graft-versus-host disease (bone marrow transplant rejection), multiple sclerosis (MS), opioid withdrawal, schizophrenia, and smoking cessation. CBD is also used to alleviate Parkinson’s symptoms, but there are some studies that advise against it.
A review and meta-analysis of 8 studies with low-quality evidence of cannabis-based medicines found that they were better at reducing sleep problems compared to inactive medicines (placebo).