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CBD, CBG, CBN & CBC Explained A mature cannabis plant contains hundreds of different compounds which can be further divided into categories of either flavonoids, terpenes, or cannabinoids, with Cannabigerol is a rare cannabinoid derived from the cannabis plant. Learn more about its effects and uses.

CBD, CBG, CBN & CBC Explained

A mature cannabis plant contains hundreds of different compounds which can be further divided into categories of either flavonoids, terpenes, or cannabinoids, with each of these having different properties and effects on the human body. Two of the most prevalent compounds in medical marijuana are THC and CBD, with THC causing the intoxicating “high” that many people attribute to marijuana use.

CBD

Cannabidiol (CBD) is derived directly from the hemp plant, which is a cousin of the marijuana plant. It does not cause an intoxicating “high” like THC does, and according to the World Health Organization, it “exhibits no effects indicative of any abuse or dependence potential. To date, there is no evidence of public health-related problems associated with the use of pure CBD.” Several benefits of CBD use include:

  • Non-intoxicating
  • Pain & inflammation reduction
  • Anxiety reduction
  • Sleep benefits
  • Seizure reduction

While CBD has grown to be the most popular non-intoxicating cannabinoid in recent years, there are also several similar compounds which exist that have shown to benefit the human body as well.

CBG

Cannabigerol (CBG) is a non-intoxicating cannabinoid similar to CBD, though this compound interacts with your body through very different mechanisms than CBD. Initial research has indicated that CBG acts as an agonist of the CB1 and CB2 receptors without causing any intoxicating effects. CBG may also act as a GABA reuptake inhibitor. This means that CBG may have a relationship with both neuropathic pain and inflammatory pain. The main benefits attained through use of CBG include:

  • Non-intoxicating
  • Digestive benefits
  • Antibacterial benefits
  • Pain & inflammation reduction
CBN

Cannabinol (CBN) is currently only attainable by deriving it from CBD through a chemical conversion. While more structurally similar to THC than CBD once it reaches its final form, CBN lacks the psychoactive effects of THC which could allow more patients to utilize it without fear of intoxication or impairment. Some of the potential benefits of CBN include:

  • Non-intoxicating
  • Antibacterial benefits
  • Neuroprotection
  • Appetite-stimulation
  • Sleep benefits
CBC

Cannabichromene (CBC) is “newer” to the cannabinoid scene as far as research is concerned, but has shown great potential as a medical supplement thus far. While its effects feel very similar to CBD when ingested, the chemical structure of the CBC is unique and offers it the capability to affect the body in a different way than CBD. So far, research has linked CBC with the following medical benefits:

  • Non-intoxicating
  • Cancer benefits
  • Neuroprotection
  • Neuroregeneration
  • Analgesic benefits

At Remedy Pain Solutions, we strive to provide our patients as many natural treatment options as possible, including these compounds we have been discussing in this article. We have a full line of organic, medical-grade CBD products that are available for our patients at our Marina Del Rey office location. If you are suffering from pain and inflammation, schedule an appointment with one of our specialists at Remedy Pain Solutions to discuss what natural options might be available to treat your symptoms so you can return to pain-free life.

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What Is Cannabigerol (CBG)?

Toketemu has been multimedia storyteller for the last four years. Her expertise focuses primarily on mental wellness and women’s health topics.

Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.

Verywell / Alex Dos Diaz

What Is Cannabigerol (CBG)?

Cannabigerol (CBG) is a type of cannabinoid obtained from the cannabis plant. It’s often referred to as the mother of all cannabinoids. This is because other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.

Other more common cannabinoids obtained from cannabis plants include cannabidiol (CBD) and tetrahydrocannabinol (THC).

CBG is found in smaller quantities than other cannabinoids in cannabis plants. In most strains of the plant, only 1% of CBG can be found compared to 20 to 25% of CBD or 25 to 30% of THC.  

This makes consumer products derived from the cannabinoid rare and often expensive. However, CBG is growing in popularity as a result of the host of potential benefits the cannabinoid has to offer.

How CBG Is Made

CBG is derived from young cannabis plants because they contain higher amounts of CBG than fully developed plants.

Some strains of cannabis like White CBG, Super Glue CBG, and Jack Frost CBG also have higher CBG content than other strains. These strains are specifically cultivated to produce higher quantities of CBG.

Both CBD and THC start as CBGA, an acidic form of CBG. This is why younger cannabis plants contain higher concentrations of CBG.

In fully developed plants with high concentrations of THC and CBD, you’ll find very low concentrations of CBG. This happens because most of the CBG has already been converted to CBD and THC as the plant developed.

Due to the difficulty of getting CBG, cannabis growers have been experimenting with cross-breeding and genetic manipulation to help cannabis plants produce more CBG.

How CBG Works

CBG is processed by the body’s endocannabinoid system. The endocannabinoid system is made up of molecules and receptors in our bodies that are responsible for keeping our bodies in an optimal state regardless of what’s going on in our external environment.

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In our bodies, CBG imitates endocannabinoids , the natural compounds our body makes.

Cannabinoid Receptors in the Body

Our body contains two types of cannabinoid receptors—CB1 and CB2. CB1 receptors are found in the nervous system and brain, while CB2 receptors are located in the immune system and other areas of the body.

CBG works by binding to both receptors where it’s thought to strengthen the function of anandamide, a neurotransmitter that plays a role in enhancing pleasure and motivation, regulating appetite and sleep, and alleviating pain. Unlike THC, CBG has no psychotropic effects, so it will not give you a high.

Potential Benefits of CBG

Like CBD, CBG has been used to combat pain without having the intoxicating effect of cannabinoids like THC.

Research shows that CBG can also have therapeutic effects. However, human studies on this are sparse and more research needs to be done in this area.

Some promising animal studies show that CBG might ultimately be found useful for the following therapeutic benefits listed below.

Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease is a condition that causes chronic inflammation in the bowel. It affects millions of people across the globe and is incurable.

An experimental animal study conducted in 2013 observed the beneficial effects of CBG on inflammatory bowel disease.

Researchers induced inflammations similar to IBD in the colons of mice and then administered CBG. CBG was found to reduce the inflammation and the production of nitric oxide. It also reduced the formation of reactive oxygen species (ROS) in the intestines. They concluded that CBG should be considered for clinical experimentation in IBD patients.

Glaucoma

In an animal study, researchers found that CBG has therapeutic potential for the treatment of glaucoma.

Reseachers administered CBG to cats with glaucoma and noticed a reduction in eye pressure and an increase in aqueous humor outflow, a fluid produced by the eye which maintains eye pressure and provides the eye with nutrition.  

Huntington’s Disease

Huntington’s disease is a condition that causes a breakdown of nerve cells in the brain. In a 2015 study, researchers examined the potential neuroprotective properties of CBG and other cannabinoids in mice who had an experimental model of Huntington’s disease.

It was observed that CBG acted as a neuroprotectant, protecting the nerve cells in your brain from damage. It also improves motor deficits and preserves striatal neurons against 3-nitropropionic acid toxicity.

Antibacterial Properties

A 2020 study on the antibiotic potential of cannabis, found that CBG has antibacterial properties. Especially against methicillin-resistant strains of Staphylococcus aureus (MRSA), a bacteria which causes staph infections and is drug-resistant.  

Fighting Cancer Cells

In a 2014 study, researchers observed the effects of CBG on rats with colon cancer. They observed that CBG showed some promise in blocking the receptors that cause cancer cell growth and inhibiting the growth of colorectal cancer cells.

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They suggested that the use of CBG should be considered translationally in the cure and prevention of colon cancer.  

How to Use CBG

The most common way CBG is produced for consumers is as an oil. You can get the benefits of CBG by using pure CBG oil. However, CBG oils are rare and expensive.

The good news is that you can also get some of the benefits of CBG from using broad-spectrum CBD oils. Broad-spectrum CBD oils contain all the cannabinoids found in a cannabis plant including CBG, but it doesn’t include THC.

When cannabinoids are used together, they can increase the effectiveness of each other by a phenomenon called the entourage effect.

CBG vs. CBD

CBG is often compared to CBD because it shares many similarities and they both act on the endocannabinoid system.

Both CBG and CBD are non-psychoactive which means they will not alter your state of mind in the way THC will.

They can however reduce the psychotropic effect of THC if you consume a cannabis plant. One of the biggest differences between CBD and CBG is the quantity which is found in most cannabis plants. Most cannabis plants contain only 1% of CBG, but up to 25% of CBD.

The way CBG interacts with our endocannabinoid system is different from CBD. CBG binds directly to both CB1 and CB2 receptors and might be more efficient at delivering its benefits into our systems.

CBG Scarcity

The production difficulties of CBG makes it very scarce. It’s much harder to produce than other cannabinoids like THC and CBD. Since CBG shares many similarities with CBD, manufacturers would rather produce CBD.

When CBG is produced, products derived from it are very expensive. However, CBG has a host of promising potential benefits and more research is being done into easing the production and availability of the cannabinoid.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Orrego-González E, Londoño-Tobón L, Ardila-González J, Polania-Tovar D, Valencia-Cárdenas A, Velez-Van Meerbeke A. Cannabinoid effects on experimental colorectal cancer models reduce aberrant crypt foci (Acf) and tumor volume: a systematic review. Evidence-Based Complementary and Alternative Medicine. 2020;2020:1-13.

By Toketemu Ohwovoriole
Toketemu has been multimedia storyteller for the last four years. Her expertise focuses primarily on mental wellness and women’s health topics.

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